Spatial and single-cell transcriptomics decipher the cellular environment containing HLA-G+ cancer cells and SPP1+ macrophages in colorectal cancer

Yuki Ozato, Yasuhiro Kojima, Yuta Kobayashi, +34

Cell Reports

ImmunologyPathologyCrc CellsCancer BiologySpatial Omics +16

Celecoxib enhances radiosensitivity of hypoxic glioblastoma cells through endoplasmic reticulum stress

Kenshi Suzuki, Ariungerel Gerelchuluun, Zhengshan Hong, +4

Neuro-Oncology

Novel Subtype-Selective Nonpeptide Bradykinin Receptor Antagonists FR167344 and FR173657

Ichiro Aramori, Junko Zenkoh, Noriyuki Morikawa, +6

Molecular Pharmacology

Nonpeptide Mimic of Bradykinin with Long-Acting Properties at the Bradykinin B2 Receptor

Ichiro Aramori, Junko Zenkoh, Noriyuki Morikawa, +14

Molecular Pharmacology

Whole-genome sequencing reveals the molecular implications of the stepwise progression of lung adenocarcinoma

Yasuhiko Haga, Yoshitaka Sakamoto, Keiko Kajiya, +18

Nature Communications

Comprehensive single-cell analysis demonstrates radiotherapy-induced infiltration of macrophages expressing immunosuppressive genes into tumor in esophageal squamous cell carcinoma

Hidekazu Oyoshi, Junyan Du, Shunsuke A. Sakai, +19

Science Advances

Esophageal CancerImmunologyImmunoeditingImmunotherapyTumor Biology +18

A phase I study on combined therapy with proton-beam radiotherapy and in situ tumor vaccination for locally advanced recurrent hepatocellular carcinoma

Masato Abei, Toshiyuki Okumura, Kuniaki Fukuda, +15

Radiation Oncology

Spatial and single-cell colocalisation analysis reveals MDK-mediated immunosuppressive environment with regulatory T cells in colorectal carcinogenesis

Masahiro Hashimoto, Yasuhiro Kojima, Takeharu Sakamoto, +40

EBioMedicine

Subtype- and species-selectivity of a tachykinin receptor antagonist, FK888, for cloned rat and human tachykinin receptors

Ichiro Aramori, Noriyuki Morikawa, Junko Zenkoh, +7

European Journal of Pharmacology Molecular Pharmacology

Signal TransductionFunctional SelectivityMedicineImmunologyReceptor (Biochemistry) +8

Spatially resolved gene expression profiling of tumor microenvironment reveals key steps of lung adenocarcinoma development

Yuma Takano, Jun Suzuki, Kotaro Nomura, +19

Nature Communications