Wilhelmus J. A. Kersten

Structure-guided design of a selective BCL-XL inhibitor

Guillaume Lessène, Peter E. Czabotar, Brad E. Sleebs et al. · Nature Chemical Biology · 2013 · 374 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis

Emma J. Petrie, Jarrod J. Sandow, Annette V. Jacobsen et al. · Nature Communications · 2018 · 193 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

Viral MLKL Homologs Subvert Necroptotic Cell Death by Sequestering Cellular RIPK3

Emma J. Petrie, Jarrod J. Sandow, Wil I. L. Lehmann et al. · Cell Reports · 2019 · 126 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

Quinazoline Sulfonamides as Dual Binders of the Proteins B-Cell Lymphoma 2 and B-Cell Lymphoma Extra Long with Potent Proapoptotic Cell-Based Activity

Brad E. Sleebs, Peter E. Czabotar, Wayne J. Fairbrother et al. · Journal of Medicinal Chemistry · 2011 · 70 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

Characterization of the Novel Broad-Spectrum Kinase Inhibitor CTx-0294885 As an Affinity Reagent for Mass Spectrometry-Based Kinome Profiling

Luxi Zhang, Ian P. Holmes, Falko Hochgräfe et al. · Journal of Proteome Research · 2013 · 53 citations

Life Sciences, Biochemistry, Oncology +14