Total Synthesis of Bryostatin 1

Gary E. Keck, Yam B. Poudel, Thomas J. Cummins, +2

Journal of the American Chemical Society

Medicinal ChemistryBiosynthesisBioorganic ChemistryBiochemistryNatural Sciences +11

A Pd(0)-Mediated Indole (Macro)cyclization Reaction

Steven P. Breazzano, Yam B. Poudel, Dale L. Boger

Journal of the American Chemical Society

Combinatorial ChemistryMedicinal ChemistryCross-coupling ReactionHeterocyclicBiochemistry +11

Streamlined Total Synthesis of Uncialamycin and Its Application to the Synthesis of Designed Analogues for Biological Investigations

K. C. Nicolaou, Yanping Wang, Min Lu, +15

Journal of the American Chemical Society

Combinatorial ChemistryBioorganic ChemistryEngineeringOrganic ChemistryPharmaceutical Chemistry +17

Molecular Modeling, Total Synthesis, and Biological Evaluations of C9‐Deoxy Bryostatin 1

Gary E. Keck, Yam B. Poudel, Arnab Rudra, +5

Angewandte Chemie International Edition

Substitution on the A-Ring Confers to Bryopyran Analogues the Unique Biological Activity Characteristic of Bryostatins and Distinct From That of the Phorbol Esters

Gary E. Keck, Yam B. Poudel, Dennie S. Welch, +6

Organic Letters

Total synthesis of dihydrolysergic acid and dihydrolysergol: development of a divergent synthetic strategy applicable to rapid assembly of D-ring analogs

Kiyoun Lee, Yam B. Poudel, Christopher M. Glinkerman, +1

Tetrahedron

D-ring AnalogsBiosynthesisBioorganic ChemistryEngineeringBiochemistry +8

Chemical Modification of Linkers Provides Stable Linker–Payloads for the Generation of Antibody–Drug Conjugates

Yam B. Poudel, Naidu S. Chowdari, Heng Cheng, +8

ACS Medicinal Chemistry Letters

Universal Affinity Capture Liquid Chromatography-Mass Spectrometry Assay for Evaluation of Biotransformation of Site-Specific Antibody Drug Conjugates in Preclinical Studies

Srikanth Kotapati, David Passmore, Sayumi Yamazoe, +12

Analytical Chemistry

Immunocytochemical TechniqueEngineeringImmunologyPayload MetabolismNanomedicine +19

Synthesis of a <i>des</i>-B-Ring Bryostatin Analogue Leads to an Unexpected Ring Expansion of the Bryolactone Core

Matthew B. Kraft, Yam B. Poudel, Noémi Kedei, +4

Journal of the American Chemical Society

Medicinal ChemistryBioorganic ChemistryBiochemistryNatural SciencesDes-b-ring Bryostatin Analogue +6

Design, synthesis and biological evaluation of phenol-linked uncialamycin antibody-drug conjugates

Yam B. Poudel, Chetana Rao, Srikanth Kotapati, +16

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryPolymer-drug ConjugateMedicineNatural Sciences +7