CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes

Luke A. Gilbert, Matthew H. Larson, Leonardo Morsut, +10

Cell

Transcriptional RegulationNatural SciencesMolecular BiologyGene EditingGenome Editing +4

STIM2 Is a Feedback Regulator that Stabilizes Basal Cytosolic and Endoplasmic Reticulum Ca2+ Levels

Onn Brandman, Jen Liou, Wei Sun Park, +1

Cell

Feedback RegulatorMolecular PhysiologySignal TransductionMolecular RegulationCell Signaling +9

A Ribosome-Bound Quality Control Complex Triggers Degradation of Nascent Peptides and Signals Translation Stress

Onn Brandman, Jacob Stewart-Ornstein, Daisy Y.L. Wong, +12

Cell

Protein FunctionProtein ExpressionProtein FoldingProtein BiosynthesisMolecular Biology +6

Interlinked Fast and Slow Positive Feedback Loops Drive Reliable Cell Decisions

Onn Brandman, James E. Ferrell, Rong Li, +1

Science

Positive FeedbackEngineeringSignal RecognitionMolecular BiologyCalcium Signaling +22

Rqc2p and 60 <i>S</i> ribosomal subunits mediate mRNA-independent elongation of nascent chains

Peter Shen, Joseph Park, Yidan Qin, +9

Science

Cellular Control of Viscosity Counters Changes in Temperature and Energy Availability

Laura Persson, Vardhaan Ambati, Onn Brandman

Cell

EngineeringDifferential Scanning CalorimetryCellular ControlPhysiologyViscosity Counters Changes +9

Functional Repurposing Revealed by Comparing S. pombe and S. cerevisiae Genetic Interactions

Adam Frost, Marc Elgort, Onn Brandman, +9

Cell

S. PombeFunctional GenomicsMedicineGeneticsNatural Sciences +12

Asc1, Hel2, and Slh1 couple translation arrest to nascent chain degradation

Cole S. Sitron, Joseph H. Park, Onn Brandman

RNA

Molecular phenotyping of aging in single yeast cells using a novel microfluidic device

Zhengwei Xie, Yi Zhang, Ke Zou, +4

Aging Cell

EngineeringAgingNovel Microfluidic DeviceCell CycleSingle Cell Sequencing +19

Single Cell Analysis of Yeast Replicative Aging Using a New Generation of Microfluidic Device

Yi Zhang, Chunxiong Luo, Ke Zou, +4

PLoS ONE

EngineeringFluorescent ReportersNew DeviceAnalytical MicrosystemsBiofabrication +14