GDF15 mediates the effects of metformin on body weight and energy balance

Anthony P. Coll, Michael Chen, Pranali Taskar, +30

Nature

ObesityMetabolic SyndromeEnergy HomeostasisEnergy MetabolismEnergy Balance +8

GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans

Satish Patel, Anna Álvarez-Guaita, Audrey Melvin, +32

Cell Metabolism

Novel role for anti-Müllerian hormone in the regulation of GnRH neuron excitability and hormone secretion

Irène Cimino, Filippo Casoni, Xinhuai Liu, +13

Nature Communications

HypoMap—a unified single-cell gene expression atlas of the murine hypothalamus

Lukas Steuernagel, Brian Lam, Paul Klemm, +16

Nature Metabolism

Systems BiologySingle Cell SequencingMedicineNeuroendocrine MechanismSingle-cell Genomics +4

GDF15 linked to maternal risk of nausea and vomiting during pregnancy

Marlena S. Fejzo, Nuno Rocha, Irène Cimino, +40

Nature

Heterogeneity of hypothalamic pro-opiomelanocortin-expressing neurons revealed by single-cell RNA sequencing

Brian Lam, Irène Cimino, Joseph Polex-Wolf, +12

Molecular Metabolism

Semaphorin7A regulates neuroglial plasticity in the adult hypothalamic median eminence

Jyoti Parkash, Andrea Messina, Fanny Langlet, +15

Nature Communications

MC3R links nutritional state to childhood growth and the timing of puberty

Brian Lam, Alice Williamson, Sarah Finer, +37

Nature

NutritionBody CompositionDevelopmental BiologyGrowth HormoneMedicine +9

Inhibition of mitochondrial function by metformin increases glucose uptake, glycolysis and GDF-15 release from intestinal cells

Ming Yang, Tamana Darwish, Pierre Larraufie, +12

Scientific Reports

Mitochondrial DysfunctionMetabolic RemodelingType2 DiabetesInsulin SignalingMetformin Increases +20

A survey of the mouse hindbrain in the fed and fasted states using single-nucleus RNA sequencing

Georgina K.C. Dowsett, Brian Lam, John A. Tadross, +7

Molecular Metabolism