David Alagille

One-step synthesis of 2-arylbenzothiazole (‘BTA’) and -benzoxazole precursors for in vivo imaging of β-amyloid plaques

David Alagille, Ronald M. Baldwin, Gilles Tamagnan · Tetrahedron Letters · 2005 · 141 citations

Medicine, Medicinal Chemistry, Pharmacology +14

[18F]GTP1 (Genentech Tau Probe 1), a radioligand for detecting neurofibrillary tangle tau pathology in Alzheimer’s disease

Sandra Sanabria Bohórquez, Annie Ogasawara, Jeff N. Tinianow et al. · European Journal of Nuclear Medicine and Molecular Imaging · 2019 · 130 citations

Life Sciences, Neurology, Neuroscience +13

Substituent Effects of<i>N</i>-(1,3-Diphenyl-1<i>H</i>-pyrazol-5-yl)benzamides on Positive Allosteric Modulation of the Metabotropic Glutamate-5 Receptor in Rat Cortical Astrocytes

Tomas de Paulis, Yelin Chen, Yongqin Zhang et al. · Journal of Medicinal Chemistry · 2006 · 129 citations · Full text

Life Sciences, Neuroscience, Pharmacology +16

A Close Structural Analog of 2-Methyl-6-(phenylethynyl)-pyridine Acts as a Neutral Allosteric Site Ligand on Metabotropic Glutamate Receptor Subtype 5 and Blocks the Effects of Multiple Allosteric Modulators

Alice L. Rodriguez, Yi Nong, Nishant K. Sekaran et al. · Molecular Pharmacology · 2005 · 125 citations

Medicine, Neuroscience, Pharmacology +17

Metabotropic glutamate receptor 5 antagonist protects dopaminergic and noradrenergic neurons from degeneration in MPTP-treated monkeys

Gunasingh Masilamoni, James W. Bogenpohl, David Alagille et al. · Brain · 2011 · 117 citations · Full text

Medicine, Neuroscience, Pharmacology +17