Genome Editing in hPSCs Reveals GATA6 Haploinsufficiency and a Genetic Interaction with GATA4 in Human Pancreatic Development

Zhong‐Dong Shi, Kihyun Lee, Dapeng Yang, +9

Cell stem cell

Developmental BiologyDevelopmental GeneticsGeneticsGene CharacterizationMolecular Genetics +5

Genome-scale screens identify JNK–JUN signaling as a barrier for pluripotency exit and endoderm differentiation

Qing V. Li, Gary Dixon, Nipun Verma, +21

Nature Genetics

Genome-scale ScreensTranscriptional RegulationInduced Pluripotent Stem CellDevelopmental BiologyPluripotency Exit +11

QSER1 protects DNA methylation valleys from de novo methylation

Gary Dixon, Heng Pan, Dapeng Yang, +18

Science

Epithelial cell plasticity drives endoderm formation during gastrulation

Katharina Scheibner, Silvia Schirge, Ingo Burtscher, +11

Nature Cell Biology

Epiblast CellsPrimitive StreakCellular PhysiologyClassical EmtEpithelial-mesenchymal Transition +18

MLL3 loss drives metastasis by promoting a hybrid epithelial–mesenchymal transition state

Jihong Cui, Chi Zhang, Ji‐Eun Lee, +10

Nature Cell Biology

Tumor BiologyCell RegulationMedicineCancer Cell BiologyEpithelial-mesenchymal Interactions +6

Dynamic network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer gene regulatory activity during cell state transitions

Renhe Luo, Jielin Yan, Jin Woo Oh, +16

Nature Genetics

Off-target EffectNatural SciencesMolecular BiologyCell State TransitionsGene Editing +6

DICER1 Is Essential for Self-Renewal of Human Embryonic Stem Cells

Virginia Teijeiro, Dapeng Yang, Sonali Majumdar, +7

Stem Cell Reports

CRISPR screening uncovers a central requirement for HHEX in pancreatic lineage commitment and plasticity restriction

Dapeng Yang, Hyunwoo Cho, Zakieh Tayyebi, +22

Nature Cell Biology

Developmental BiologyPlasticity RestrictionCentral RequirementGeneticsGene Editing +5

miR-335 promotes mesendodermal lineage segregation and shapes a transcription factor gradient in the endoderm

Dapeng Yang, Dominik Lutter, Ingo Burtscher, +3

Development

Glucose Transporters Are Key Components of the Human Glucostat

Inbal Caspi, Daniel M. Tremmel, Julián Pulecio, +5

Diabetes