H. Gingell

Optimization of a Novel Binding Motif to (<i>E</i>)-3-(3,5-Difluoro-4-((1<i>R</i>,3<i>R</i>)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1<i>H</i>-pyrido[3,4-<i>b</i>]indol-1-yl)phenyl)acrylic Acid (AZD9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist

Chris De Savi, Robert H. Bradbury, Alfred A. Rabow et al. · Journal of Medicinal Chemistry · 2015 · 160 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Pyridomycin bridges the NADH- and substrate-binding pockets of the enoyl reductase InhA

Ruben C. Hartkoorn, Florence Pojer, Jon Read et al. · Nature Chemical Biology · 2013 · 73 citations · Full text

Life Sciences, Biochemistry, Medicinal Chemistry +9

Rapid Generation of a High Quality Lead for Transforming Growth Factor-β (TGF-β) Type I Receptor (ALK5)

Frederick W. Goldberg, Richard A. Ward, Steven J. Powell et al. · Journal of Medicinal Chemistry · 2009 · 43 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Tetrahydroisoquinoline Phenols: Selective Estrogen Receptor Downregulator Antagonists with Oral Bioavailability in Rat

James S. Scott, Andrew Bailey, Robert D. M. Davies et al. · ACS Medicinal Chemistry Letters · 2015 · 42 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16