Takayuki Okamoto

Site-specific PEGylation of a lysine-deficient TNF-α with full bioactivity

Yoko Yamamoto, Yasuo Tsutsumi, Yasuo Yoshioka et al. · Nature Biotechnology · 2003 · 208 citations

Life Sciences, Biochemistry, Biotechnology +13

The use of PVP as a polymeric carrier to improve the plasma half-life of drugs

Yoshihisa Kaneda, Yasuo Tsutsumi, Yasuo Yoshioka et al. · Biomaterials · 2003 · 188 citations

Pharmacy, Pharmaceutics, Pharmacokinetics +13

Astrocytic phagocytosis is a compensatory mechanism for microglial dysfunction

Hiroyuki Konishi, Takayuki Okamoto, Yuichiro Hara et al. · The EMBO Journal · 2020 · 180 citations · Full text

Life Sciences, Neurobiology, Neuroscience +12

Synthesis of a poly(vinylpyrrolidone-co -dimethyl maleic anhydride) co-polymer and its application for renal drug targeting

Haruhiko Kamada, Yasuo Tsutsumi, Keiko Sato‐Kamada et al. · Nature Biotechnology · 2003 · 118 citations

Natural Sciences, Chemistry, Pharmaceutics +14

Reduced substrate stiffness promotes M2-like macrophage activation and enhances peroxisome proliferator-activated receptor γ expression

Takayuki Okamoto, Yoshimi Takagi, Eiji Kawamoto et al. · Experimental Cell Research · 2018 · 105 citations

Life Sciences, Cell Biology, Immunology +12