ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis

Yao Shi, Fedor Nikulenkov, Joanna Zawacka‐Pankau, +9

Cell Death and Differentiation

Tumor BiologyOncogenic AgentMedicineApoptosisRos-dependent Activation +9

High levels of thioredoxin reductase 1 modulate drug-specific cytotoxic efficacy

Sofi Eriksson, Stefanie Prast‐Nielsen, Emilie Flaberg, +2

Free Radical Biology and Medicine

Reductive StressBiochemistryRedox RegulatorMedicineToxicology +5

Dietary methionine can sustain cytosolic redox homeostasis in the mouse liver

Sofi Eriksson, Justin R. Prigge, Emily A. Talago, +2

Nature Communications

Cytosolic Redox HomeostasisLipid PeroxidationRedox BiologyOxidative StressHepatotoxicity +18

Glutathione-dependent hydrogen donor system for calf thymus ribonucleoside-diphosphate reductase.

Mikaela Luthman, Sofi Eriksson, Arne Holmgren, +1

Proceedings of the National Academy of Sciences

Cellular EnzymologyBiochemistryNatural Monothiol GlutathioneMedicineNatural Sciences +7

TrxR1, Gsr, and oxidative stress determine hepatocellular carcinoma malignancy

Michael McLoughlin, David J. Orlicky, Justin R. Prigge, +16

Proceedings of the National Academy of Sciences

p53-dependent inhibition of TrxR1 contributes to the tumor-specific induction of apoptosis by RITA

Elisabeth Hedström, Sofi Eriksson, Joanna Zawacka‐Pankau, +2

Cell Cycle

ApoptosisCell DeathPathologyP53-dependent InhibitionThioredoxin Reductase 1 +15

A Txnrd1-dependent metabolic switch alters hepatic lipogenesis, glycogen storage, and detoxification

Sonya V. Iverson, Sofi Eriksson, Jianqiang Xu, +7

Free Radical Biology and Medicine

Metabolic SyndromeBiochemistryLiver PhysiologyPhysiologyMetabolic Regulation +9

Hepatocyte DNA replication in growing liver requires either glutathione or a single allele of txnrd1

Justin R. Prigge, Sofi Eriksson, Sonya V. Iverson, +4

Free Radical Biology and Medicine

Single AlleleHepatologyNatural SciencesLiver PhysiologyGenetics +7

Mitochondrial peroxiredoxin 3 is rapidly oxidized in cells treated with isothiocyanates

Kristin Brown, Sofi Eriksson, Elias S.J. Arnér, +1

Free Radical Biology and Medicine

Mitochondrial FunctionBiochemistryNatural SciencesReactive Oxygen SpecieCellular Biochemistry +7

Sepp1UF forms are N-terminal selenoprotein P truncations that have peroxidase activity when coupled with thioredoxin reductase-1

Suguru Kurokawa, Sofi Eriksson, Kristie L. Rose, +10

Free Radical Biology and Medicine

Redox SignalingBiochemistryNatural SciencesThioredoxin Reductase-1Medicine +7