Derivation of Human Trophoblast Stem Cells

Hiroaki Okae, Hidehiro Toh, Tetsuya Sato, +7

Cell stem cell

Developmental BiologyMedicineAdult Stem CellStem Cell ResearchStem Cells +2

Mouse Oocyte Methylomes at Base Resolution Reveal Genome-Wide Accumulation of Non-CpG Methylation and Role of DNA Methyltransferases

Kenjiro Shirane, Hidehiro Toh, Hisato Kobayashi, +5

PLoS Genetics

Non-cpg MethylationGeneticsDna MethylationEpigenetic ChangeGenomic Mechanism +19

Generation of human oogonia from induced pluripotent stem cells in vitro

Chika Yamashiro, Kotaro Sasaki, Yukihiro Yabuta, +10

Science

<i>Setdb1</i> is required for germline development and silencing of H3K9me3-marked endogenous retroviruses in primordial germ cells

Sheng Liu, Julie Brind’Amour, Mohammad M. Karimi, +6

Genes & Development

Most RetrotransposonsEpigenetic ChangeGeneticsDna MethylationGenomic Mechanism +22

In Vitro Derivation and Propagation of Spermatogonial Stem Cell Activity from Mouse Pluripotent Stem Cells

Yukiko Ishikura, Yukihiro Yabuta, Hiroshi Ohta, +8

Cell Reports

SpermatogenesisFertilityGeneticsAdult Stem CellReproductive Biology +24

NSD1-deposited H3K36me2 directs de novo methylation in the mouse male germline and counteracts Polycomb-associated silencing

Kenjiro Shirane, Fumihito Miura, Takashi Ito, +1

Nature Genetics

ChromatinDevelopmental BiologyChromatin StructureNsd1-deposited H3k36me2Germ Cell +13

DNA methylation and gene expression dynamics during spermatogonial stem cell differentiation in the early postnatal mouse testis

Naoki Kubo, Hidehiro Toh, Kenjiro Shirane, +14

BMC Genomics

Asparaginyl endopeptidase of jack bean seeds. Purification, characterization, and high utility in protein sequence analysis.

Yasuaki Abe, Kenjiro Shirane, Hideyoshi Yokosawa, +4

Journal of Biological Chemistry

Protein Sequence AnalysisEngineeringGlycobiologyMolecular BiologyEnzymatic Modification +18

Global Landscape and Regulatory Principles of DNA Methylation Reprogramming for Germ Cell Specification by Mouse Pluripotent Stem Cells

Kenjiro Shirane, Kazuki Kurimoto, Yukihiro Yabuta, +7

Developmental Cell

Germ Cell BiologyChromatinGlobal LandscapeInduced Pluripotent Stem CellEpigenetic Change +11

Allele-Specific Methylome and Transcriptome Analysis Reveals Widespread Imprinting in the Human Placenta

Hirotaka Hamada, Hiroaki Okae, Hidehiro Toh, +8

The American Journal of Human Genetics

EmbryologyHuman PlacentaDevelopmental BiologyEpigenetic ChangeGenetics +9