Validation and application of Caco-2 assays for the<b><i>in vitro</i></b>evaluation of development candidate drugs as substrates or inhibitors of P-glycoprotein to support regulatory submissions

Robert Elsby, Dominic Surry, Veronica Smith, +1

Xenobiotica

Pharmaceutical ScienceCellular PharmacologyDevelopment Candidate DrugsPharmacotherapySystem Pharmacology +22

Antagonists of the Human A_2A Adenosine Receptor. 4. Design, Synthesis, and Preclinical Evaluation of 7-Aryltriazolo[4,5-<i>d</i>]pyrimidines

Roger J. Gillespie, Samantha J. Bamford, Ruth Botting, +23

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryStriatal DopamineBiochemistryDopaminergic Neurons +12

Solitary Inhibition of the Breast Cancer Resistance Protein Efflux Transporter Results in a Clinically Significant Drug-Drug Interaction with Rosuvastatin by Causing up to a 2-Fold Increase in Statin Exposure

Robert Elsby, Paul Martin, Dominic Surry, +2

Drug Metabolism and Disposition

Gene expression profiling of drug metabolism and toxicology markers using a low-density DNA microarray

Françoise de Longueville, Dominic Surry, Georgina Meneses‐Lorente, +9

Biochemical Pharmacology

Functional GenomicsPredictive ToxicologyMedicineDna MicroarraysForensic Toxicology +9

Comparison of the effects of some CYP3A and other enzyme inducers on replicative DNA synthesis and cytochrome P450 isoforms in rat liver

Brian G. Lake, A. B. Renwick, Morag E. Cunninghame, +3

Toxicology

BiochemistryMedicineLiver PhysiologyNatural SciencesCytochrome P450 Isoforms +9

Metabolism of 7-benzyloxy-4-trifluoromethylcoumarin by human hepatic cytochrome P450 isoforms

A. B. Renwick, Dominic Surry, Roger J. Price, +2

Xenobiotica

Metabolomic ProfilingToxicological MechanismOther Cyp IsoformsToxicologyHepatotoxicity +15

Prediction of the in vivo OATP1B1-mediated drug–drug interaction potential of an investigational drug against a range of statins

Pradeep Sharma, Caroline Butters, Veronica Smith, +2

European Journal of Pharmaceutical Sciences

Pharmacological StudyBiochemistryMedicineInvestigational DrugPharmacotherapy +4

Effects of Fostamatinib on the Pharmacokinetics of Oral Contraceptive, Warfarin, and the Statins Rosuvastatin and Simvastatin: Results From Phase I Clinical Studies

Paul Martin, Michael Gillen, James M. Ritter, +7

Drugs in R&D

Validation of membrane vesicle-based breast cancer resistance protein and multidrug resistance protein 2 assays to assess drug transport and the potential for drug–drug interaction to support regulatory submissions

Robert Elsby, Veronica Smith, Lisa Fox, +4

Xenobiotica

Metabolism of 2,5-bis(trifluoromethyl)-7-benzyloxy-4-trifluoromethylcoumarin by human hepatic CYP isoforms: evidence for selectivity towards CYP3A4

A. B. Renwick, David F. Lewis, S. Fulford, +8

Xenobiotica

Nadph-dependent Bfbfc MetabolismSelectivity Towards Cyp3a4Toxicological MechanismMolecular PharmacologyHepatotoxicity +15