Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia

Adriana E. Tron, Matthew A. Belmonte, Ammar Adam, +31

Nature Communications

Metabolism of the human immunodeficiency virus protease inhibitors indinavir and ritonavir by human intestinal microsomes and expressed cytochrome P4503A4/3A5: mechanism-based inactivation of cytochrome P4503A by ritonavir.

T. Koudriakova, Eugenia Iatsimirskaia, Ilya Utkin, +6

PubMed

Cytochrome P4503aMetabolomic ProfilingAntiviral DrugAntiviral Drug DevelopmentEnzyme Kinetic Parameters +16

Reduction of Signal Suppression Effects in ESI-MS Using a Nanosplitting Device

Eric T. Gangl, Meg Annan, Neil Spooner, +1

Analytical Chemistry

EngineeringAnalytical MicrosystemsFlow CellSignal Suppression EffectsBiomedical Engineering +19

Discovery of AZD9833, a Potent and Orally Bioavailable Selective Estrogen Receptor Degrader and Antagonist

James S. Scott, Amber Balazs, Bernard Barlaam, +42

Journal of Medicinal Chemistry

Design and optimisation of dendrimer-conjugated Bcl-2/xL inhibitor, AZD0466, with improved therapeutic index for cancer therapy

Claire Patterson, Srividya B. Balachander, Iain Grant, +28

Communications Biology

Structural elucidation of metabolites of ritonavir and indinavir by liquid chromatography–mass spectrometry

Eric T. Gangl, Ilya Utkin, Nicolas Gerber, +1

Journal of Chromatography A

Liquid Chromatography–mass SpectrometryBiochemistryStructural ElucidationMedicineMass Spectrometry +8

Discovery of Pyrazolo[1,5-<i>a</i>]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors

William McCoull, Roman Abrams, Erica Anderson, +31

Journal of Medicinal Chemistry

Subatmospheric electrospray interface for coupling of microcolumn separations with mass spectrometry

František Foret, Haihong Zhou, Eric T. Gangl, +1

Electrophoresis

EngineeringAnalytical MicrosystemsBiological Mass SpectrometryLiquid JunctionBiomedical Engineering +15

Novel heterocyclic DPP-4 inhibitors for the treatment of type 2 diabetes

Jon M. Sutton, David E. Clark, Stephen J. Dunsdon, +18

Bioorganic & Medicinal Chemistry Letters

Diabetes ManagementBiochemistryMedicineDiabetesType 2 +6

AZD4320, A Dual Inhibitor of Bcl-2 and Bcl-xL, Induces Tumor Regression in Hematologic Cancer Models without Dose-limiting Thrombocytopenia

Srividya B. Balachander, Steven W. Criscione, Kate F. Byth, +35

Clinical Cancer Research