Eric T. Gangl

Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia

Adriana E. Tron, Matthew A. Belmonte, Ammar Adam et al. · Nature Communications · 2018 · 479 citations · Full text

Metabolism of the human immunodeficiency virus protease inhibitors indinavir and ritonavir by human intestinal microsomes and expressed cytochrome P4503A4/3A5: mechanism-based inactivation of cytochrome P4503A by ritonavir.

T. Koudriakova, Eugenia Iatsimirskaia, Ilya Utkin et al. · PubMed · 1998 · 243 citations

Cytochrome P4503a, Metabolomic Profiling, Antiviral Drug +18

Reduction of Signal Suppression Effects in ESI-MS Using a Nanosplitting Device

Eric T. Gangl, Meg Annan, Neil Spooner et al. · Analytical Chemistry · 2001 · 180 citations

Engineering, Analytical Microsystems, Flow Cell +21

Discovery of AZD9833, a Potent and Orally Bioavailable Selective Estrogen Receptor Degrader and Antagonist

James S. Scott, Amber Balazs, Bernard Barlaam et al. · Journal of Medicinal Chemistry · 2020 · 109 citations · Full text

Design and optimisation of dendrimer-conjugated Bcl-2/xL inhibitor, AZD0466, with improved therapeutic index for cancer therapy

Claire Patterson, Srividya B. Balachander, Iain Grant et al. · Communications Biology · 2021 · 89 citations · Full text