Therapeutically targeting glypican-3 via a conformation-specific single-domain antibody in hepatocellular carcinoma

Mingqian Feng, Wei Gao, Ruoqi Wang, +6

Proceedings of the National Academy of Sciences

Inactivation of Wnt signaling by a human antibody that recognizes the heparan sulfate chains of glypican-3 for liver cancer therapy

Wei Gao, Heungnam Kim, Mingqian Feng, +4

Hepatology

Immunotoxin targeting glypican-3 regresses liver cancer via dual inhibition of Wnt signalling and protein synthesis

Wei Gao, Zhewei Tang, Yifan Zhang, +4

Nature Communications

Functional EpitopeImmunologyPathologyImmunotherapyCancer Biology +17

Randomized Trial of Molnupiravir or Placebo in Patients Hospitalized with Covid-19

José Ramón Arribas, Sanjay Bhagani, Suzana M. Lobo, +16

NEJM Evidence

Adverse EventsClinical Infectious DiseaseCovid-19 PandemicOral ProdrugClinical Trials +12

A Frizzled‐Like Cysteine‐Rich Domain in Glypican‐3 Mediates Wnt Binding and Regulates Hepatocellular Carcinoma Tumor Growth in Mice

Na Li, Liwen Wei, Xiaoyu Liu, +12

Hepatology

Shed antigen-induced blocking effect on CAR-T cells targeting Glypican-3 in Hepatocellular Carcinoma

Luan Sun, Fang Gao, Zhanhui Gao, +11

Journal for ImmunoTherapy of Cancer

Insight into the practical performance of RT-PCR testing for SARS-CoV-2 using serological data: a cohort study

Zhen Zhang, Qifang Bi, Shisong Fang, +12

The Lancet Microbe

Rubus idaeus L. (red raspberry) blocks UVB-induced MMP production and promotes type I procollagen synthesis via inhibition of MAPK/AP-1, NF-κβ and stimulation of TGF-β/Smad, Nrf2 in normal human dermal fibroblasts

Wei Gao, Yu‐shuai Wang, Eunson Hwang, +5

Journal of Photochemistry and Photobiology B Biology

Rubus Idaeus L.Signal TransductionRed RaspberryUvb-induced Mmp ProductionHuman Growth +12

High-affinity monoclonal antibodies to cell surface tumor antigen glypican-3 generated through a combination of peptide immunization and flow cytometry screening

Yen Phung, Wei Gao, Yan‐Gao Man, +2

mAbs

Immunocytochemical TechniqueImmunologyPathologyImmunophenotypingImmunotherapy +16

Human Monoclonal Antibody Targeting the Heparan Sulfate Chains of Glypican-3 Inhibits HGF-Mediated Migration and Motility of Hepatocellular Carcinoma Cells

Wei Gao, Heungnam Kim, Mitchell Ho

PLoS ONE

ImmunologyHepatocellular Carcinoma CellsCancer BiologyTumor BiologyMutant Gpc3 +18