Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment

William L. Hwang, Karthik A. Jagadeesh, Jimmy A. Guo, +62

Nature Genetics

Trajectory AnalysisTumor BiologyPancreatic CancerTumor HeterogeneitySpatial Transcriptome Profiling +11

Conversion of Danger Signals into Cytokine Signals by Hematopoietic Stem and Progenitor Cells for Regulation of Stress-Induced Hematopoiesis

Jimmy L. Zhao, Chao Ma, Ryan M. O’Connell, +3

Cell stem cell

InflammationCytokineDanger SignalsMedicineStem Cell Mobilization +10

Longitudinal proteomic analysis of severe COVID-19 reveals survival-associated signatures, tissue-specific cell death, and cell-cell interactions

Michael R. Filbin, Arnav Mehta, Alexis M. Schneider, +40

Cell Reports Medicine

Radiation therapy enhances immunotherapy response in microsatellite stable colorectal and pancreatic adenocarcinoma in a phase II trial

Aparna R. Parikh, Annamária Szabolcs, Jill N. Allen, +28

Nature Cancer

Radiation MedicineMicrosatellite Stable ColorectalPancreatic CancerRadiation TherapyRadiation Therapy Enhances +7

Temporal and spatial heterogeneity of host response to SARS-CoV-2 pulmonary infection

Niyati Desai, Azfar Neyaz, Annamária Szabolcs, +30

Nature Communications

An NF-κB-microRNA regulatory network tunes macrophage inflammatory responses

Mati Mann, Arnav Mehta, Jimmy L. Zhao, +6

Nature Communications

In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer

Juan Dubrot, Peter P. Du, Sarah Kate Lane-Reticker, +30

Nature Immunology

Tumor BiologyImmunologyTumor ImmunityVivo Crispr ScreensGene Editing +8

Heterogeneous Responses of Hematopoietic Stem Cells to Inflammatory Stimuli Are Altered with Age

Mati Mann, Arnav Mehta, Carl G. de Boer, +8

Cell Reports

Immunotherapy Resistance by Inflammation-Induced Dedifferentiation

Arnav Mehta, Yeon Joo Kim, Lídia Robert, +8

Cancer Discovery

Combined PD-1, BRAF and MEK inhibition in BRAFV600E colorectal cancer: a phase 2 trial

Jun Tian, Jonathan Chen, Sherry Chao, +42

Nature Medicine