Molecular patterns of response and treatment failure after frontline venetoclax combinations in older patients with AML

Courtney D. DiNardo, Ing Soo Tiong, Anna Quaglieri, +26

Blood

Chemotherapy and Venetoclax in Elderly Acute Myeloid Leukemia Trial (CAVEAT): A Phase Ib Dose-Escalation Study of Venetoclax Combined With Modified Intensive Chemotherapy

Chong Chyn Chua, Andrew W. Roberts, John Reynolds, +12

Journal of Clinical Oncology

ImmunologyPharmacotherapyTumor BiologyMyeloid NeoplasiaHematological Malignancy +16

Combining BH3-mimetics to target both BCL-2 and MCL1 has potent activity in pre-clinical models of acute myeloid leukemia

Donia M. Moujalled, Giovanna Pomilio, Corina Ghiurau, +24

Leukemia

Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias

Rachel Thijssen, Sarah T. Diepstraten, Donia M. Moujalled, +33

Blood

Acquired mutations in BAX confer resistance to BH3-mimetic therapy in acute myeloid leukemia

Donia M. Moujalled, Fiona C. Brown, Chong Chyn Chua, +22

Blood

Hematological MalignancyBax Confer ResistanceMedicineAcute Myeloid LeukemiaMixed-phenotype Acute Leukemia +12

A Cancer Vaccine Induces Expansion of NY-ESO-1-Specific Regulatory T Cells in Patients with Advanced Melanoma

Lisa M. Ebert, Sarah MacRaild, Damien Zanker, +3

PLoS ONE

A risk-reward examination of sample multiplexing reagents for single cell RNA-Seq

Daniel V. Brown, Casey J. A. Anttila, Ling Ling, +26

Genomics

EngineeringTranscriptomics TechnologySample Multiplexing ReagentsSingle Cell SequencingSingle Cell Rna-seq +17

Acquired Mutations in BAX Confer Resistance to BH3 Mimetics in Acute Myeloid Leukemia

Donia M. Moujalled, Fiona C. Brown, Giovanna Pomilio, +17

Blood

Molecular Patterns of Response and Outcome in the Chemotherapy and Venetoclax in Elderly AML Trial (CAVEAT study)

Andrew H. Wei, Chong Chyn Chua, Ing Soo Tiong, +12

Blood

The Influence of the Zebrafish Genetic Background on Parkinson's Disease–Related Aspects

Sandrine Bretaud, Sarah MacRaild, Philip W. Ingham, +1

Zebrafish

GeneticsSocial SciencesNeurobiology Of DiseaseDisease–related AspectsExperimental Neuropathology +16