Natural regulatory mutations elevate the fetal globin gene via disruption of BCL11A or ZBTB7A binding

Gabriella E. Martyn, Beeke Wienert, Lu Yang, +9

Nature Genetics

Developmental BiologyZbtb7a BindingGenetic DisorderGeneticsFetal Globin Gene +7

Extracellular vesicle associated long non-coding RNAs functionally enhance cell viability

Chris Hewson, David Capraro, Jon Burdach, +2

Non-coding RNA Research

KLF1 directly activates expression of the novel fetal globin repressor ZBTB7A/LRF in erythroid cells

Laura J. Norton, Alister P. W. Funnell, Jon Burdach, +7

Blood Advances

Loss of Krüppel-Like Factor 3 (KLF3/BKLF) Leads to Upregulation of the Insulin-Sensitizing Factor Adipolin (FAM132A/CTRP12/C1qdc2)

Kim Bell‐Anderson, Alister P. W. Funnell, Helen Williams, +12

Diabetes

Metabolic RemodelingFam132a PromoterAdipokinesInsulin SignalingObesity +19

Regions outside the DNA-binding domain are critical for proper in vivo specificity of an archetypal zinc finger transcription factor

Jon Burdach, Alister P. W. Funnell, Kimberley S. Mak, +6

Nucleic Acids Research

ChromatinTranscriptional RegulationSystems BiologyFunctional GenomicsVivo Specificity +12

The CACCC-Binding Protein KLF3/BKLF Represses a Subset of KLF1/EKLF Target Genes and Is Required for Proper Erythroid Maturation <i>In Vivo</i>

Alister P. W. Funnell, Laura J. Norton, Ka Sin Mak, +14

Molecular and Cellular Biology

Long Non-coding RNA BGas Regulates the Cystic Fibrosis Transmembrane Conductance Regulator

Sheena Saayman, Amanda Ackley, Jon Burdach, +6

Molecular Therapy

<i>MYCNOS</i> functions as an antisense RNA regulating <i>MYCN</i>

Nadia Vadie, Sheena Saayman, Alexandra Lenox, +6

RNA Biology

A CpG Mutational Hotspot in a ONECUT Binding Site Accounts for the Prevalent Variant of Hemophilia B Leyden

Alister P. W. Funnell, Michael D. Wilson, Benoît Ballester, +9

The American Journal of Human Genetics

Genetic DisorderGeneticsPathogenesisHematologyCpg Mutational Hotspot +6

Repression of chimeric transcripts emanating from endogenous retrotransposons by a sequence-specific transcription factor

Ka Sin Mak, Jon Burdach, Laura J. Norton, +3

Genome biology