Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, Kotb Abdelmohsen, Akihisa Abe, +2329

Autophagy

C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking

Manal A. Farg, Vinod Sundaramoorthy, Jessica M. Sultana, +9

Human Molecular Genetics

Intronic ExpansionMolecular BiologyCytoskeletonAutophagyEndocytic Pathway +21

ALS-Associated TDP-43 Induces Endoplasmic Reticulum Stress, Which Drives Cytoplasmic TDP-43 Accumulation and Stress Granule Formation

Adam K. Walker, Kai Y. Soo, Vinod Sundaramoorthy, +8

PLoS ONE

Cell DeathNeurochemical BiomarkersEr StressStress Granule FormationSynaptic Signaling +22

The DNA damage response (DDR) is induced by the C9orf72 repeat expansion in amyotrophic lateral sclerosis

Manal A. Farg, Anna Konopka, Kai Y. Soo, +2

Human Molecular Genetics

C9orf72 Repeat ExpansionGeneticsMolecular BiologyDisease Gene IdentificationRepeat Expansions +16

Rab1-dependent ER–Golgi transport dysfunction is a common pathogenic mechanism in SOD1, TDP-43 and FUS-associated ALS

Kai Y. Soo, Mark A. Halloran, Vinod Sundaramoorthy, +8

Acta Neuropathologica

Neurodegenerative DiseasesAmyotrophic Lateral SclerosisCommon Pathogenic MechanismDegenerative DiseaseDegenerative Pathology +7

Ataxin-2 interacts with FUS and intermediate-length polyglutamine expansions enhance FUS-related pathology in amyotrophic lateral sclerosis

Manal A. Farg, Kai Y. Soo, Sadaf T. Warraich, +3

Human Molecular Genetics

Mutant FUS induces endoplasmic reticulum stress in amyotrophic lateral sclerosis and interacts with protein disulfide-isomerase

Manal A. Farg, Kai Y. Soo, Adam K. Walker, +7

Neurobiology of Aging

Amyotrophic Lateral SclerosisProtein Disulfide-isomeraseProtein FoldingNatural SciencesMedicine +5

Extracellular wildtype and mutant SOD1 induces ER–Golgi pathology characteristic of amyotrophic lateral sclerosis in neuronal cells

Vinod Sundaramoorthy, Adam K. Walker, Justin J. Yerbury, +6

Cellular and Molecular Life Sciences

Extracellular WildtypeNeurodegenerative DiseasesAmyotrophic Lateral SclerosisNeurological DisorderNeuronal Cells +9

Bim Links ER Stress and Apoptosis in Cells Expressing Mutant SOD1 Associated with Amyotrophic Lateral Sclerosis

Kai Y. Soo, Julie D. Atkin, Manal A. Farg, +3

PLoS ONE

Neurodegenerative DiseasesBear InclusionsAmyotrophic Lateral SclerosisBiochemistryMitochondrial Function +11

Recruitment of mitochondria into apoptotic signaling correlates with the presence of inclusions formed by amyotrophic lateral sclerosis‐associated SOD1 mutations

Kai Y. Soo, Julie D. Atkin, Malcolm Horne, +1

Journal of Neurochemistry

GeneticsApoptosisCell DeathMolecular BiologySod1 Mutations +17