AXL and Error-Prone DNA Replication Confer Drug Resistance and Offer Strategies to Treat EGFR-Mutant Lung Cancer

Ashish Noronha, Nishanth Belugali Nataraj, Joo Sang Lee, +36

Cancer Discovery

Targeting HER3, a Catalytically Defective Receptor Tyrosine Kinase, Prevents Resistance of Lung Cancer to a Third-Generation EGFR Kinase Inhibitor

Donatella Romaniello, Ilaria Marrocco, Nishanth Belugali Nataraj, +15

Cancers

ImmunologyHer3 CleavageCancer BiologyTumor BiologyPrevents Resistance +14

PD-L1 recruits phospholipase C and enhances tumorigenicity of lung tumors harboring mutant forms of EGFR

Soma Ghosh, Nishanth Belugali Nataraj, Ashish Noronha, +19

Cell Reports

Tumor BiologyLung TumorsMedicineCancer Cell BiologyPathology +8

ETS Proteins Bind with Glucocorticoid Receptors: Relevance for Treatment of Ewing Sarcoma

Swati Srivastava, Nishanth Belugali Nataraj, Arunachalam Sekar, +20

Cell Reports

Nucleoporin-93 reveals a common feature of aggressive breast cancers: robust nucleocytoplasmic transport of transcription factors

Nishanth Belugali Nataraj, Ashish Noronha, Joo Sang Lee, +19

Cell Reports

Upfront admixing antibodies and EGFR inhibitors preempts sequential treatments in lung cancer models

Ilaria Marrocco, Donatella Romaniello, Itay Vaknin, +9

EMBO Molecular Medicine

Targeting autocrine amphiregulin robustly and reproducibly inhibits ovarian cancer in a syngeneic model: roles for wildtype p53

Moshit Lindzen, Soma Ghosh, Ashish Noronha, +13

Oncogene

TSHZ2 is an EGF-regulated tumor suppressor that binds to the cytokinesis regulator PRC1 and inhibits metastasis

Mary Luz Uribe, Maik Dahlhoff, R.N. Batra, +14

Science Signaling

Combined TRIP13 and Aurora Kinase Inhibition Induces Apoptosis in Human Papillomavirus–Driven Cancers

Soma Ghosh, Tuhina Mazumdar, Wei Xu, +9

Clinical Cancer Research

Hpv-driven CancersApoptosisCell DeathCancer BiologyHuman Papillomavirus–driven Cancers +14

Sustained Aurora Kinase B Expression Confers Resistance to PI3K Inhibition in Head and Neck Squamous Cell Carcinoma

Pooja A. Shah, Vaishnavi Sambandam, Anne M. Fernandez, +9

Cancer Research