CHANGES OF MICRO-RNA EXPRESSION IN RAT LIVER TREATED BY ACETAMINOPHEN OR CARBON TETRACHLORIDE − REGULATING ROLE OF MICRO-RNA FOR RNA EXPRESSION −

Tamio Fukushima, Yoshimasa Hamada, Hiroshi Yamada, +1

The Journal of Toxicological Sciences

PathologyEpigeneticsOxidative StressToxicologyHepatotoxicity +18

INVESTIGATION OF A HEPATOTOXICITY SCREENING SYSTEM IN PRIMARY CELL CULTURES-"WHAT BIOMARKERS WOULD NEED TO BE ADDRESSED TO ESTIMATE TOXICITY IN CONVENTIONAL AND NEW APPROACHES?"-

Rie Kikkawa, Toshinori Yamamoto, Tamio Fukushima, +2

The Journal of Toxicological Sciences

PathologyToxicological MechanismOxidative StressBioanalysisToxicology +16

AP2 adaptor complex mediates bile salt export pump internalization and modulates its hepatocanalicular expression and transport function

Hisamitsu Hayashi, Kaori Inamura, Kensuke Aida, +9

Hepatology

EFFECTS OF MALE REPRODUCTIVE TOXICANTS ON GENE EXPRESSION IN RAT TESTES

Tamio Fukushima, Toshinori Yamamoto, Rie Kikkawa, +4

The Journal of Toxicological Sciences

Effects of Sulfasalazine on Sperm Acrosome Reaction and Gene Expression in the Male Reproductive Organs of Rats

Tamio Fukushima, Masashi Kato, Tetsuya Adachi, +5

Toxicological Sciences

SpermatogenesisFertilityMale Reproductive OrgansGeneticsCd59 Protein +22

Rational Design of Novel 1,3-Oxazine Based β-Secretase (BACE1) Inhibitors: Incorporation of a Double Bond To Reduce P-gp Efflux Leading to Robust Aβ Reduction in the Brain

Kouki Fuchino, Yasunori Mitsuoka, Moriyasu Masui, +22

Journal of Medicinal Chemistry

Discovery of Potent and Centrally Active 6-Substituted 5-Fluoro-1,3-dihydro-oxazine β-Secretase (BACE1) Inhibitors via Active Conformation Stabilization

Kenji Nakahara, Kouki Fuchino, Kazuo Komano, +20

Journal of Medicinal Chemistry

Chemical BiologyPharmaceutical ChemistryPre-clinical PharmacologyMolecular PharmacologyMedicinal Chemistry +18

Multiple cytokine activities and loss of interleukin 2 inhibitor in synovial fluids of patients with rheumatoid arthritis.

Noriko Yamagata, Katsuyuki Kobayashi, Tsuyoshi Kasama, +7

PubMed

Multiple Cytokine ActivitiesImmunologyPathologyPsoriatic ArthritisInflammatory Arthritis +17

Early changes in sperm motility, acrosome reaction, and gene expression of reproductive organs in rats treated with sulfasalazine

Tamio Fukushima, Yoshimasa Hamada, Masatoshi Komiyama, +3

Reproductive Toxicology

SpermatogenesisInfertilityAndrologyDevelopmental BiologyFertility +11

PROTEIN EXPRESSION ANALYSIS OF RAT TESTES INDUCED TESTICULAR TOXICITY WITH SEVERAL REPRODUCTIVE TOXICANTS

Toshinori Yamamoto, Tamio Fukushima, Rie Kikkawa, +2

The Journal of Toxicological Sciences

SpermatogenesisFertilityGeneticsGynecologyReproductive Biology +21