AP2 adaptor complex mediates bile salt export pump internalization and modulates its hepatocanalicular expression and transport function

Abstract

AP2 mediates the internalization and subsequent degradation of CM-resident BSEP through direct interaction with BSEP and thereby modulates the canalicular expression and transport function of BSEP. This information should be useful for understanding the pathogenesis of severe liver diseases associated with intrahepatic cholestasis.