ASP2151, a novel helicase-primase inhibitor, possesses antiviral activity against varicella-zoster virus and herpes simplex virus types 1 and 2

Koji Chono, Kiyomitsu Katsumata, Toru Kontani, +6

Journal of Antimicrobial Chemotherapy

Novel 7H-pyrrolo[2,3-d]pyrimidine derivatives as potent and orally active STAT6 inhibitors

S. Nagashima, Takeshi Hondo, Hiroshi Nagata, +14

Bioorganic & Medicinal Chemistry

Medicinal ChemistryPharmaceutical ScienceBiochemistryMedicineActive Stat6 Inhibitors +7

Identification, Synthesis, and Biological Evaluation of 6-[(6<i>R</i>)-2-(4-Fluorophenyl)-6-(hydroxymethyl)-4,5,6,7-tetrahydropyrazolo[1,5-<i>a</i>]pyrimidin-3-yl]-2-(2-methylphenyl)pyridazin-3(2<i>H</i>)-one (AS1940477), a Potent p38 MAP Kinase Inhibitor

Toru Asano, Hitoshi Yamazaki, Chiyoshi Kasahara, +10

Journal of Medicinal Chemistry

Characterization of virus strains resistant to the herpes virus helicase–primase inhibitor ASP2151 (Amenamevir)

Koji Chono, Kiyomitsu Katsumata, Toru Kontani, +2

Biochemical Pharmacology

Helicase–primase Inhibitor Asp2151Molecular VirologyNeurovirologyVirus StrainsAntiviral Drug Development +8

Effect of ASP2151, a Herpesvirus Helicase-Primase Inhibitor, in a Guinea Pig Model of Genital Herpes

Kiyomitsu Katsumata, Koji Chono, Kenji Sudo, +3

Molecules

Therapeutic EffectMolecular VirologyMedicinePathogenesisViral Pathogenesis +12

Pharmacokinetics and Pharmacodynamics of ASP2151, a Helicase-Primase Inhibitor, in a Murine Model of Herpes Simplex Virus Infection

Kiyomitsu Katsumata, Koji Chono, Kota Kato, +4

Antimicrobial Agents and Chemotherapy

Translational MedicineViral PersistenceMedicineMurine ModelImmunology +11

Synthesis and Pharmacological Characterization of Novel 6-Fluorochroman Derivatives as Potential 5-HT_1A Receptor Antagonists

Tomoyuki Yasunaga, Takenori Kimura, Ryo Naito, +7

Journal of Medicinal Chemistry

Studies of non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 2: Synthesis and structure–activity relationships of 2-cyano and 2-hydroxy thiazolidenebenzenesulfonamide derivatives

Naoyuki Masuda, Osamu Yamamoto, Masahiro Fujii, +21

Bioorganic & Medicinal Chemistry

Medicinal Chemistry2-Hydroxy Thiazolidenebenzenesulfonamide DerivativesBiochemistryMedicineNatural Sciences +8

Susceptibility of Herpes Simplex Virus Isolated from Genital Herpes Lesions to ASP2151, a Novel Helicase-Primase Inhibitor

Kiyomitsu Katsumata, Adriana Weinberg, Koji Chono, +3

Antimicrobial Agents and Chemotherapy

Studies of nonnucleoside HIV-1 reverse transcriptase inhibitors. Part 1: Design and synthesis of thiazolidenebenzenesulfonamides

Naoyuki Masuda, Osamu Yamamoto, Masahiro Fujii, +21

Bioorganic & Medicinal Chemistry

Medicinal ChemistryBioorganic ChemistryBiochemistryMedicineNatural Sciences +8