TGF-ß Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia

Neil A. Bhowmick, Anna Chytil, David Plieth, +6

Science

Stromal CellsAdjacent EpitheliaPathologyCell ProliferationCancer Biology +19

Discovering the anticancer potential of non-oncology drugs by systematic viability profiling

Steven M. Corsello, Rohith T. Nagari, Ryan D. Spangler, +35

Nature Cancer

Tumor BiologySystematic Viability ProfilingMedicineCancer ManagementPharmacology +10

Blockade of TGF-β inhibits mammary tumor cell viability, migration, and metastases

Rebecca S. Muraoka, Nancy Dumont, Christoph A. Ritter, +9

Journal of Clinical Investigation

Soluble FcMedicineImmunologyCancer Cell BiologyImmune Checkpoint Inhibitor +9

WRN helicase is a synthetic lethal target in microsatellite unstable cancers

Edmond M. Chan, Tsukasa Shibue, James M. McFarland, +38

Nature

Microsatellite Unstable CancersOncogenic AgentMedicineMolecular BiologyCancer Genomics +6

Blockade of TGF-β inhibits mammary tumor cell viability, migration, and metastases

Rebecca S. Muraoka, Nancy Dumont, Christoph A. Ritter, +9

Journal of Clinical Investigation

Breast Cancer MetastasesSoluble FcCancer ImmunosurveillanceMedicineTgf-β Signaling +10

Sustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basal-like breast cancers

Nancy Dumont, Matthew B. Wilson, Yongping Crawford, +3

Proceedings of the National Academy of Sciences

Epigenetic ChangeDna MethylationCancer BiologyEpigeneticsTumor Biology +16

CD36 Repression Activates a Multicellular Stromal Program Shared by High Mammographic Density and Tumor Tissues

Rosa Anna DeFilippis, Hang Chang, Nancy Dumont, +14

Cancer Discovery

Intravenous injection of soluble antigen induces thymic and peripheral T-cells apoptosis.

Roland Liblau, Roland Tisch, Kevan M. Shokat, +4

Proceedings of the National Academy of Sciences

ImmunologyImmune RegulationImmunodominanceAntigen ProcessingPeripheral Apoptosis +16

Breast Fibroblasts Modulate Early Dissemination, Tumorigenesis, and Metastasis through Alteration of Extracellular Matrix Characteristics

Nancy Dumont, Bob Liu, Rosa Anna DeFilippis, +7

Neoplasia

Breast OncologyMedicineExtracellular Matrix CharacteristicsPathologyCell-matrix Interaction +7

Dual Role of Transforming Growth Factor β in Mammary Tumorigenesis and Metastatic Progression

Rebecca S. Muraoka-Cook, Nancy Dumont, Carlos L. Arteaga

Clinical Cancer Research