The gene encoding the prostatic tumor suppressor PSP94 is a target for repression by the Polycomb group protein EZH2

Lijs Beke, Mieke Nuytten, Aleyde Van Eynde, +2

Oncogene

Transcriptional RegulationNatural SciencesMolecular BiologyTumor SuppressorProstatic Disease +5

The transcriptional repressor NIPP1 is an essential player in EZH2-mediated gene silencing

Mieke Nuytten, Lijs Beke, Aleyde Van Eynde, +5

Oncogene

ChromatinTranscriptional RegulationTranscriptional Repressor Nipp1Ezh2-mediated GeneGenetics +7

MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells

Lijs Beke, Joannes T. M. Linders, Shannah Boens, +13

Bioscience Reports

Protein Kinase MelkCell DeathDna-damage ToleranceCancer BiologyTumor Biology +14

Nucleocytoplasmic Shuttling of the Splicing Factor SIPP1

Miriam Llorian, Monique Beullens, Bart Lesage, +5

Journal of Biological Chemistry

Maternal Embryonic Leucine Zipper Kinase (MELK) Reduces Replication Stress in Glioblastoma Cells

Monique Beullens, Lijs Beke, Aleyde Van Eynde, +3

Journal of Biological Chemistry

The phosphatase interactor NIPP1 regulates the occupancy of the histone methyltransferase EZH2 at Polycomb targets

Nele Van Dessel, Lijs Beke, Janina Görnemann, +6

Nucleic Acids Research

Histone ModificationsMolecular RegulationEpigenetic ChangeMolecular BiologyEpigenetics +23

Fragment-Based Discovery of Type I Inhibitors of Maternal Embryonic Leucine Zipper Kinase

Christopher N. Johnson, Valério Berdini, Lijs Beke, +17

ACS Medicinal Chemistry Letters

Drug TargetFragment-based Drug DesignMolecular BiologyPeptide ScienceChemical Biology +20

Structure-Based Design of Type II Inhibitors Applied to Maternal Embryonic Leucine Zipper Kinase

Christopher N. Johnson, Christophe Adelinet, Valério Berdini, +18

ACS Medicinal Chemistry Letters

Abstract 4859: JNJ-64619178, a selective and pseudo-irreversible PRMT5 inhibitor with potent <i>in vitro</i> and <i>in vivo</i> activity, demonstrated in several lung cancer models

Tongfei Wu, Hillary J. Millar, Dana Gaffney, +14

Cancer Research

Abstract 4859PharmacotherapyCancer BiologyEpigeneticsSplicing Variant +21

A Chemical Probe for the Methyl Transferase PRMT5 with a Novel Binding Mode

Vineet Pande, Weimei Sun, Lijs Beke, +13

ACS Medicinal Chemistry Letters