Kevin X. Chen - Concepedia

Author

Kevin X. Chen

Merck & Co., Inc., Rahway, NJ, USA (United States)ORCID

Also Known As

Chen, Kevin X., Kevin X Chen, Kevin X. Chen

Publications

1.3K

Citations

H-Index

Concepts

All Affiliations

Merck & Co., Inc., Rahway, NJ, USA (United States)AIL Research (United States)WuXi AppTec (China)Constellation Pharmaceuticals (United States)

About

Kevin X. Chen is an author at Merck & Co., Inc., Rahway, NJ, USA (United States) specializing in pharmacology, medicine, and drug discovery.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Medicine	15	18	530
2	Biochemistry	13	13	380
3	Natural Sciences	10	10	251
4	Biomolecular Engineering	8	8	192
5	Engineering	2	2	49

Kevin X. Chen

Publications

911

Citations

H-Index

Page 1

	Year	Citations
GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP) F. Anthony Romero, Jeremy Murray, Kwong Wah Lai, Journal of Medicinal Chemistry	2017	125
Discovery of Narlaprevir (SCH 900518): A Potent, Second Generation HCV NS3 Serine Protease Inhibitor Ashok Arasappan, Frank Bennett, Stéphane Bogen, ACS Medicinal Chemistry Letters Protease InhibitorsMedicinal ChemistrySynthetic VirologyMedicineSynthetic Sequence	2010	95
Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300 Terry D. Crawford, F. Anthony Romero, Kwong Wah Lai, Journal of Medicinal Chemistry	2016	94
Discovery and Structure−Activity Relationship of P<sub>1</sub>−P<sub>3</sub> Ketoamide Derived Macrocyclic Inhibitors of Hepatitis C Virus NS3 Protease Srikanth Venkatraman, Francisco Velázquez, Wanli Wu, Journal of Medicinal Chemistry Analogue 52Antiviral CompoundHepatologyBiochemistryViral Hepatitis	2008	52
I. Novel HCV NS5B polymerase inhibitors: Discovery of indole 2-carboxylic acids with C3-heterocycles G. Anilkumar, Charles A. Lesburg, Oleg Selyutin, Bioorganic & Medicinal Chemistry Letters BiochemistryMedicineIndole 2-Carboxylic AcidsAntiviral Drug DevelopmentAntiviral Drug	2011	49
Potent 7-Hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid-Based Macrocyclic Inhibitors of Hepatitis C Virus NS3 Protease Kevin X. Chen, F. George Njoroge, John Pichardo, Journal of Medicinal Chemistry Medicinal ChemistryNs3 ProteaseBiochemistryMedicineNatural Sciences	2005	42
Novel Dipeptide Macrocycles from 4-Oxo, -Thio, and -Amino-Substituted Proline Derivatives Ashok Arasappan, Kevin X. Chen, F. George Njoroge, The Journal of Organic Chemistry Combinatorial ChemistryBioorganic ChemistryEngineeringBiochemistryNovel Dipeptide Macrocycles	2002	38
Novel Potent Hepatitis C Virus NS3 Serine Protease Inhibitors Derived from Proline-Based Macrocycles Kevin X. Chen, F. George Njoroge, Ashok Arasappan, Journal of Medicinal Chemistry	2006	38
Second-Generation Highly Potent and Selective Inhibitors of the Hepatitis C Virus NS3 Serine Protease Kevin X. Chen, Latha G. Nair, Bancha Vibulbhan, Journal of Medicinal Chemistry Hepatitis C VirusSelective InhibitorsAntiviral DrugRibavirin Combination TherapyMedicinal Chemistry	2009	33
Structure–Activity Relationship (SAR) Development and Discovery of Potent Indole-Based Inhibitors of the Hepatitis C Virus (HCV) NS5B Polymerase Kevin X. Chen, Bancha Vibulbhan, Weiying Yang, Journal of Medicinal Chemistry Structure–activity RelationshipPharmaceutical ScienceViral Polymerase StructureHepatitis C VirusIndole Core	2011	30

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