Characterization of a novel androgen receptor mutation in a relapsed CWR22 prostate cancer xenograft and cell line.

Clifford G. Tepper, David L. Boucher, Philip Ryan, +5

PubMed

Tumor BiologyMedicineGeneticsHormonal ReceptorCwr22rv1 Cell Line +13

<i>O</i>-GlcNAc Modification Protects against Protein Misfolding and Aggregation in Neurodegenerative Disease

Philip Ryan, Mingming Xu, Andrew K. Davey, +4

ACS Chemical Neuroscience

GlycobiologyMolecular BiologyNeurochemical BiomarkersAmyloid Precursor ProteinSynaptic Signaling +22

The N Terminus of Cbl-c Regulates Ubiquitin Ligase Activity by Modulating Affinity for the Ubiquitin-conjugating Enzyme

Philip Ryan, Nina Sivadasan-Nair, Marion M. Nau, +2

Journal of Biological Chemistry

Profiling of gene expression changes caused by p53 gain-of-function mutant alleles in prostate cancer cells

Clifford G. Tepper, Jeffrey P. Gregg, Xu-Bao Shi, +6

The Prostate

EGFRvIII undergoes activation-dependent downregulation mediated by the Cbl proteins

Gareth Davies, Philip Ryan, Lambratu Rahman, +2

Oncogene

Signal TransductionCell RegulationCbl ProteinsGene ExpressionMedicine +2

Cbl interacts with multiple E2s in vitro and in cells

Mariya Liyasova, Ke Ma, Donna Voeller, +4

PLoS ONE

Cbl InteractsMolecular BiologyCell DeathCell CycleCbl Protein +19

T Cells in G1 Provide a Memory-Like Response to Secondary Stimulation

Ivana Munitić, Philip Ryan, Jonathan D. Ashwell

The Journal of Immunology

Secondary StimulationCell TherapyAdaptive Immune SystemT-regulatory CellImmunology +20

Cbl-c Ubiquitin Ligase Activity Is Increased via the Interaction of Its RING Finger Domain with a LIM Domain of the Paxillin Homolog, Hic 5

Philip Ryan, Stephen C. Kales, Rajgopal Yadavalli, +3

PLoS ONE

Reductive StressPaxillin HomologProtein FunctionSignal TransductionTyrosine Kinase +11

Loss of function Cbl-c mutations in solid tumors

Silvano Rakeem Daniels, Mariya Liyasova, Stephen C. Kales, +4

PLoS ONE

Function Cbl-c MutationsCbl MutationsSomatic VariantOncogenic AgentReceptor Tyrosine Kinase +10

O-GlcNAcylation of truncated NAC segment alters peptide-dependent effects on α-synuclein aggregation

Philip Ryan, Mingming Xu, Andrew K. Davey, +3

Bioorganic Chemistry

Neurodegenerative DiseasesProtein FunctionMolecular NeuroscienceBiochemistryProtein Folding +8