GM-CSF inhibition reduces cytokine release syndrome and neuroinflammation but enhances CAR-T cell function in xenografts

Rosalie M. Sterner, Reona Sakemura, Michelle J. Cox, +19

Blood

Targeting cancer-associated fibroblasts in the bone marrow prevents resistance to CART-cell therapy in multiple myeloma

Reona Sakemura, Mehrdad Hefazi, Elizabeth L. Siegler, +20

Blood

Leukemic extracellular vesicles induce chimeric antigen receptor T cell dysfunction in chronic lymphocytic leukemia

Michelle J. Cox, Fabrice Lucien, Reona Sakemura, +22

Molecular Therapy

GM-CSF disruption in CART cells modulates T cell activation and enhances CART cell anti-tumor activity

Michelle J. Cox, Claudia Manriquez Roman, Erin E. Tapper, +18

Leukemia

Cancer ImmunosurveillanceGm-csf DisruptionT-regulatory CellImmunologyImmunoediting +7

Using CRISPR/Cas9 to Knock Out GM-CSF in CAR-T Cells

Rosalie M. Sterner, Michelle J. Cox, Reona Sakemura, +1

Journal of Visualized Experiments

Mesenchymal stromal cells with chimaeric antigen receptors for enhanced immunosuppression

Olivia Sirpilla, Reona Sakemura, Mehrdad Hefazi, +21

Nature Biomedical Engineering

Cell TherapyAutoimmune DiseaseMedicineImmunosuppressive TherapyImmunology +9

Development of a Clinically Relevant Reporter for Chimeric Antigen Receptor T-cell Expansion, Trafficking, and Toxicity

Reona Sakemura, Aditya Bansal, Elizabeth L. Siegler, +24

Cancer Immunology Research

IL-4 drives exhaustion of CD8+ CART cells

Carli M. Stewart, Elizabeth L. Siegler, Reona Sakemura, +18

Nature Communications

Targeting Cancer Associated Fibroblasts in the Bone Marrow Prevents Resistance to Chimeric Antigen Receptor T Cell Therapy in Multiple Myeloma

Reona Sakemura, Michelle J. Cox, Michael J. Hansen, +10

Blood

Efficient Gene Editing of CART Cells with CRISPR-Cas12a for Enhanced Antitumor Efficacy

Elizabeth L. Siegler, Brandon W. Simone, Reona Sakemura, +10

Blood