A Mitochondrial Kinase Complex Is Essential to Mediate an ERK1/2-Dependent Phosphorylation of a Key Regulatory Protein in Steroid Biosynthesis

Cecilia Poderoso, Daniela P. Converso, Paula Maloberti, +8

PLoS ONE

Mitochondrial StarKey Regulatory ProteinOxidative StressReceptor Tyrosine KinaseAutophagy +14

Functional Interaction between Acyl-CoA Synthetase 4, Lipooxygenases and Cyclooxygenase-2 in the Aggressive Phenotype of Breast Cancer Cells

Paula Maloberti, Alejandra Duarte, Ulises Orlando, +4

PLoS ONE

Breast OncologyFunctional InteractionMetabolic RemodelingCancer BiologyTumor Biology +18

Acyl-CoA synthetase-4 is implicated in drug resistance in breast cancer cell lines involving the regulation of energy-dependent transporter expression

Ulises Orlando, Ana F. Castillo, Mayra Agustina Ríos Medrano, +3

Biochemical Pharmacology

Signal TransductionEnergy-dependent Transporter ExpressionBiochemistryMolecular PathwayMedicine +7

Silencing the expression of mitochondrial acyl‐CoA thioesterase I and acyl‐CoA synthetase 4 inhibits hormone‐induced steroidogenesis

Paula Maloberti, Rocı́o Castilla, Fabiana Cornejo Maciel, +3

FEBS Journal

GeneticsInner Mitochondrial MembraneSynthetase 4Oxidative StressBiosynthesis +18

New inhibitor targeting Acyl-CoA synthetase 4 reduces breast and prostate tumor growth, therapeutic resistance and steroidogenesis

Ana F. Castillo, Ulises Orlando, Paula Maloberti, +18

Cellular and Molecular Life Sciences

The Functional Interaction between Acyl-CoA Synthetase 4, 5-Lipooxygenase and Cyclooxygenase-2 Controls Tumor Growth: A Novel Therapeutic Target

Ulises Orlando, Juan Garona, Giselle V. Ripoll, +6

PLoS ONE

Chemoprevention StrategyFunctional InteractionNovel Therapeutic TargetMetabolic RemodelingAcyl-coa Synthetase 4 +16

An arachidonic acid-preferring acyl-CoA synthetase is a hormone-dependent and obligatory protein in the signal transduction pathway of steroidogenic hormones

Fabiana Cornejo Maciel, Paula Maloberti, Isabel Neuman, +4

Journal of Molecular Endocrinology

Acyl-CoA synthetase-4, a new regulator of mTOR and a potential therapeutic target for enhanced estrogen receptor function in receptor-positive and -negative breast cancer

Ulises Orlando, Ana F. Castillo, Melina A. Dattilo, +3

Oncotarget

Tyrosine phosphatase SHP2 regulates the expression of acyl-CoA synthetase ACSL4

Mariana Cooke, Ulises Orlando, Paula Maloberti, +2

Journal of Lipid Research

Concerted regulation of free arachidonic acid and hormone‐induced steroid synthesis by acyl‐CoA thioesterases and acyl‐CoA synthetases in adrenal cells

Paula Maloberti, Rocío Castilla Lozano, Pablo G. Mele, +5

European Journal of Biochemistry

Acyl‐coa SynthetasesOxidative StressAdrenal GlandBiosynthesisSteroid Metabolism +15