Hong Yong

Novel Erythromycin Derivatives with Aryl Groups Tethered to the C-6 Position Are Potent Protein Synthesis Inhibitors and Active against Multidrug-Resistant Respiratory Pathogens

Zhenkun Ma, Richard F. Clark, Antony Brazzale et al. · Journal of Medicinal Chemistry · 2001 · 112 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Discovery of ((4<i>R</i>,5<i>S</i>)-5-Amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8<i>H</i>)-yl)methanone (ABT-341), a Highly Potent, Selective, Orally Efficacious, and Safe Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes

Zhonghua Pei, Xiaofeng Li, Thomas W von Geldern et al. · Journal of Medicinal Chemistry · 2006 · 52 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Crystal Structures of DPP-IV (CD26) from Rat Kidney Exhibit Flexible Accommodation of Peptidase-Selective Inhibitors

Kenton L. Longenecker, Kent D. Stewart, David J. Madar et al. · Biochemistry · 2006 · 42 citations · Full text

Pharmacy, Biochemistry, Pharmacology +16

Discovery of 2-[4-{{2-(2<i>S</i>,5<i>R</i>)-2-Cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]- 4-methyl-1-piperidinyl]-4-pyridinecarboxylic Acid (ABT-279):  A Very Potent, Selective, Effective, and Well-Tolerated Inhibitor of Dipeptidyl Peptidase-IV, Useful for the Treatment of Diabetes

David J. Madar, Hana Kopecka, Daisy Pireh et al. · Journal of Medicinal Chemistry · 2006 · 37 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +10

Synthesis and antibacterial activity of novel 6-O-substituted erythromycin A derivatives

Richard F. Clark, Zhenkun Ma, Sanyi Wang et al. · Bioorganic & Medicinal Chemistry Letters · 2000 · 31 citations

Pharmacy, Chemistry, Medicinal Chemistry +15