Ken Takezawa

<i>HER2</i> Amplification: A Potential Mechanism of Acquired Resistance to EGFR Inhibition in <i>EGFR</i> -Mutant Lung Cancers That Lack the Second-Site <i>EGFR</i> T790M Mutation

Ken Takezawa, Valentina Pirazzoli, Maria E. Arcila et al. · Cancer Discovery · 2012 · 720 citations · Full text

Potent antitumor activity of MS-247, a novel DNA minor groove binder, evaluated by an in vitro and in vivo human cancer cell line panel.

Takao Yamori, A. Matsunaga, Shigeo Sato et al. · PubMed · 1999 · 262 citations

Chemoprevention Strategy, Ms-247 Mode, Human Cancer Xenografts +16

Thymidylate synthase as a determinant of pemetrexed sensitivity in non-small cell lung cancer

Ken Takezawa, Isamu Okamoto, Wataru Okamoto et al. · British Journal of Cancer · 2011 · 168 citations · Full text

Activation of HER Family Signaling as a Mechanism of Acquired Resistance to ALK Inhibitors in EML4-ALK–Positive Non–Small Cell Lung Cancer

Junko Tanizaki, Isamu Okamoto, Takafumi Okabe et al. · Clinical Cancer Research · 2012 · 154 citations

Role of ERK-BIM and STAT3-Survivin Signaling Pathways in ALK Inhibitor–Induced Apoptosis in EML4-ALK–Positive Lung Cancer

Ken Takezawa, Isamu Okamoto, Kazuto Nishio et al. · Clinical Cancer Research · 2011 · 141 citations · Full text