Cohesin promotes stochastic domain intermingling to ensure proper regulation of boundary-proximal genes

Jennifer M. Luppino, Daniel Park, Son C. Nguyen, +4

Nature Genetics

MedicineNatural SciencesGenomic MechanismMolecular BiologyGene Regulation +8

Hotspots of aberrant enhancer activity punctuate the colorectal cancer epigenome

Andrea J. Cohen, Alina Saiakhova, Olivia Corradin, +16

Nature Communications

BRD4 orchestrates genome folding to promote neural crest differentiation

Ricardo Linares-Saldana, Wonho Kim, Nikhita Bolar, +19

Nature Genetics

ChromatinCell LineageDevelopmental BiologyGeneticsGenomic Mechanism +5

Modeling disease risk through analysis of physical interactions between genetic variants within chromatin regulatory circuitry

Olivia Corradin, Andrea J. Cohen, Jennifer M. Luppino, +3

Nature Genetics

ChromatinGenetic DiseasesGenetic AnalysisDisease RiskGenetics +13

High-throughput Oligopaint screen identifies druggable 3D genome regulators

Daniel Park, Son C. Nguyen, Randi Isenhart, +18

Nature

BioinformaticsEngineeringBiomolecular ToolMedicineComputational Biology +7

Multi-feature clustering of CTCF binding creates robustness for loop extrusion blocking and Topologically Associating Domain boundaries

Li‐Hsin Chang, Sourav Ghosh, Andrea Papale, +12

Nature Communications

ARID1A spatially partitions interphase chromosomes

Shuai Wu, Nail Fatkhutdinov, Leah F. Rosin, +10

Science Advances

CTCF blocks antisense transcription initiation at divergent promoters

Jing Luan, Marit W. Vermunt, Camille M. Syrett, +15

Nature Structural & Molecular Biology

ChromatinTranscriptional RegulationMedicineGene RegulationGene Expression +3

Spatially coordinated heterochromatinization of long synaptic genes in fragile X syndrome

Thomas Malachowski, Keerthivasan Raanin Chandradoss, Ravi Boya, +17

Cell

Co-depletion of NIPBL and WAPL balance cohesin activity to correct gene misexpression

Jennifer M. Luppino, Andrew R. Field, Son C. Nguyen, +8

PLoS Genetics

Histone ModificationsGene MisexpressionGeneticsGenomic MechanismMolecular Biology +16