Automated on-chip rapid microscopy, phenotyping and sorting of C. elegans

Kwanghun Chung, Matthew M. Crane, Hang Lu

Nature Methods

BiologyCell LineageDevelopmental BiologyMicroscope Image ProcessingMicroscopy +6

Real-time multimodal optical control of neurons and muscles in freely behaving Caenorhabditis elegans

Jeffrey N. Stirman, Matthew M. Crane, Steven Husson, +4

Nature Methods

Sensorimotor ControlGanglion CellNeural MechanismPhysiological OpticComputational Neuroscience +10

A Microfluidic System for Studying Ageing and Dynamic Single-Cell Responses in Budding Yeast

Matthew M. Crane, Ivan Clark, Elco Bakker, +2

PLoS ONE

EngineeringOrgan-on-a-chipCellular PhysiologyHigh DensityYeast +15

Autonomous screening of C. elegans identifies genes implicated in synaptogenesis

Matthew M. Crane, Jeffrey N. Stirman, Chan-Yen Ou, +4

Nature Methods

Cell LineageDevelopmental BiologyAutonomous ScreeningDevelopmental GeneticsGenetics +5

Age-dependent deterioration of nuclear pore assembly in mitotic cells decreases transport dynamics

Irina L. Rempel, Matthew M. Crane, David J. Thaller, +11

eLife

Nuclear Pore AssemblyAgingAged CellsMolecular BiologyCytoskeleton +19

Computer-enhanced high-throughput genetic screens of C. elegans in a microfluidic system

Matthew M. Crane, Kwanghun Chung, Hang Lu

Lab on a Chip

EngineeringGeneticsSynthetic CircuitOrgan-on-a-chipBiological Computing +17

Transaldolase inhibition impairs mitochondrial respiration and induces a starvation-like longevity response in Caenorhabditis elegans

Christopher F. Bennett, Jane Kwon, Christine Chen, +19

PLoS Genetics

Mitochondrial DysfunctionMitochondrial BiologyRedox BiologyOxidative StressLongevity +14

A multispectral optical illumination system with precise spatiotemporal control for the manipulation of optogenetic reagents

Jeffrey N. Stirman, Matthew M. Crane, Steven Husson, +2

Nature Protocols

Optogenetic ReagentsPhotonicsLight RegulationOptical ManipulationEngineering +8

Distributing tasks via multiple input pathways increases cellular survival in stress

Alejandro A. Granados, Matthew M. Crane, Luis F. Montaño-Gutierrez, +3

eLife

P38 Map KinaseCell CycleGene Regulatory NetworkPhysiological RegulationCellular Physiology +24

Transition between fermentation and respiration determines history-dependent behavior in fluctuating carbon sources

Bram Cerulus, Abbas Jariani, Gemma Perez-Samper, +15

eLife