Pharmacogenetic Pathway Analysis for Determination of Sunitinib-Induced Toxicity

Nielka P. van Erp, Karel Eechoute, A. A. van der Veldt, +9

Journal of Clinical Oncology

Genetic Polymorphisms Associated with a Prolonged Progression-Free Survival in Patients with Metastatic Renal Cell Cancer Treated with Sunitinib

Astrid A.M. van der Veldt, Karel Eechoute, Hans Gelderblom, +7

Clinical Cancer Research

A Long-term Prospective Population Pharmacokinetic Study on Imatinib Plasma Concentrations in GIST Patients

Karel Eechoute, Martin N. Fransson, An K. Reyners, +10

Clinical Cancer Research

Sunitinib-Induced Hypothyroidism Is due to Induction of Type 3 Deiodinase Activity and Thyroidal Capillary Regression

Mariëtte H.W. Kappers, Joep H.M. van Esch, Frank Smedts, +8

The Journal of Clinical Endocrinology & Metabolism

Polymorphisms in Endothelial Nitric Oxide Synthase (eNOS) and Vascular Endothelial Growth Factor (VEGF) Predict Sunitinib-Induced Hypertension

Karel Eechoute, Astrid A.M. van der Veldt, Sjoukje F. Oosting, +9

Clinical Pharmacology & Therapeutics

HypertensionGenetic EpidemiologyPredict Sunitinib-induced HypertensionPathologyDbp Elevations +18

Environmental and Genetic Factors Affecting Transport of Imatinib by OATP1A2

Karel Eechoute, Ryan M. Franke, Walter J. Loos, +8

Clinical Pharmacology & Therapeutics

Tumor Volume as an Alternative Response Measurement for Imatinib Treated GIST Patients

Gaia Schiavon, Alessandro Ruggiero, Patrick Schöffski, +8

PLoS ONE

Predictive Value of CYP3A and ABCB1 Phenotyping Probes for the Pharmacokinetics of Sunitinib: the ClearSun Study

Jacqueline S. L. Kloth, Heinz‐Josef Klümpen, Huixin Yu, +12

Clinical Pharmacokinetics

BiochemistryMedicineClearsun StudyPredictive ValueAbcb1 Phenotyping Probes +6

Macrocytosis as a potential parameter associated with survival after tyrosine kinase inhibitor treatment

Jacqueline S. L. Kloth, Paul Hamberg, Pauline A.J. Mendelaar, +7

European Journal of Cancer

MedicineMalignant Blood DisorderReceptor Tyrosine KinaseImmunologyCell Death +9

Prospective Analysis in GIST Patients on the Role of Alpha-1 Acid Glycoprotein in Imatinib Exposure

Sander Bins, Karel Eechoute, Jacqueline S. L. Kloth, +5

Clinical Pharmacokinetics