The Ripoptosome, a Signaling Platform that Assembles in Response to Genotoxic Stress and Loss of IAPs

Tencho Tenev, Katiuscia Bianchi, Maurice Darding, +8

Molecular Cell

Genotoxic StressSystems BiologySignal TransductionNatural SciencesApoptosis +7

Mutations in the DNA methyltransferase gene DNMT3A cause an overgrowth syndrome with intellectual disability

Katrina Tatton‐Brown, Sheila Seal, Elise Ruark, +19

Nature Genetics

Down SyndromeChromatinDevelopmental BiologyMendelian DisorderOvergrowth Syndrome +9

The DIAP1 RING finger mediates ubiquitination of Dronc and is indispensable for regulating apoptosis

Rebecca Wilson, Lakshmi Goyal, Mark Ditzel, +5

Nature Cell Biology

ChromatinSignal TransductionCell RegulationMolecular RegulationNatural Sciences +8

Degradation of DIAP1 by the N-end rule pathway is essential for regulating apoptosis

Mark Ditzel, Rebecca Wilson, Tencho Tenev, +4

Nature Cell Biology

Signaling PathwayCell RegulationApoptosisAutophagyCell Death +7

Mutations in Epigenetic Regulation Genes Are a Major Cause of Overgrowth with Intellectual Disability

Katrina Tatton‐Brown, Chey Loveday, Shawn Yost, +14

The American Journal of Human Genetics

Biallelic TRIP13 mutations predispose to Wilms tumor and chromosome missegregation

Shawn Yost, Bas de Wolf, Sandra Hanks, +18

Nature Genetics

Somatic VariantCytogeneticsGenetic DisorderGeneticsPathology +5

IAPs are functionally non-equivalent and regulate effector caspases through distinct mechanisms

Tencho Tenev, Anna Zachariou, Rebecca Wilson, +2

Nature Cell Biology

Distinct MechanismsSignal TransductionSignaling PathwayMolecular RegulationCell Signaling +8

Identification of new Wilms tumour predisposition genes: an exome sequencing study

Shazia Mahamdallie, Shawn Yost, Emma Poyastro-Pearson, +24

The Lancet Child & Adolescent Health

The Tatton-Brown-Rahman Syndrome: A clinical study of 55 individuals with de novo constitutive DNMT3A variants

Katrina Tatton‐Brown, Anna Zachariou, Chey Loveday, +44

Wellcome Open Research

Germline mutations in the PAF1 complex gene CTR9 predispose to Wilms tumour

Sandra Hanks, Elizabeth R Perdeaux, Sheila Seal, +14

Nature Communications