Concepedia

Dihydroartemisinin induces endoplasmic reticulum stress-mediated apoptosis in HepG2 human hepatoma cells.

Xiaoling Gao, Ziguo Luo, Tingxiu Xiang, Kejian Wang, Jian Li, Wang Pi-long

Tumori · 2011 · 34 citations · 35 references

DOI

Concepts

Abstract

Aims and BackgroundPrevious studies showed that dihydroartemisinin (DHA) possessed antitumor activity in many human tumor cells through the induction of apoptosis. The aim of this study was to inve...

References

35

IRE1 Signaling Affects Cell Fate During the Unfolded Protein Response

Jonathan H. Lin, Han Li, Douglas Yasumura et al. · Science · 2007 · 1.4K citations

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Proapoptotic BAX and BAK Modulate the Unfolded Protein Response by a Direct Interaction with IRE1α

Claudio Hetz, Paula Bernasconi, Jill K. Fisher et al. · Science · 2006 · 661 citations

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Experimental Therapy of Hepatoma with Artemisinin and Its Derivatives: <i>In vitro</i> and <i>In vivo</i> Activity, Chemosensitization, and Mechanisms of Action

Junmei Hou, Disong Wang, Ruiwen Zhang et al. · Clinical Cancer Research · 2008 · 321 citations · Full text

, , +15

Calcium Elevation in Mitochondria Is the Main Ca2+ Requirement for Mitochondrial Permeability Transition Pore (mPTP) Opening

Heidi K. Baumgartner, Julia V. Gerasimenko, Christopher Thorne et al. · Journal of Biological Chemistry · 2009 · 270 citations · Full text

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Artesunate Induces ROS-Mediated Apoptosis in Doxorubicin-Resistant T Leukemia Cells

Thomas Efferth, Marco Giaisi, Annette Merling et al. · PLoS ONE · 2007 · 255 citations · Full text

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