Metabolic Engineering of Rational Screened Saccharopolyspora spinosa for the Enhancement of Spinosyns A and D Production

Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp.

Mary Ann Bierman, Robert M. Logan, Kathryn A. O'Brien et al. · Gene · 1992 · 1.4K citations

Conjugal Transfer, Engineering, Microbial Genetics +11

Cloning and analysis of the spinosad biosynthetic gene cluster of Saccharopolyspora spinosa

Clive Waldron, Patti Matsushima, Paul R. Rosteck et al. · Chemistry & Biology · 2001 · 212 citations · Full text

Enhanced Expression of<i>S</i>-Adenosylmethionine Synthetase Causes Overproduction of Actinorhodin in<i>Streptomyces coelicolor</i>A3(2)

Susumu Okamoto, Alexander Lezhava, Takeshi Hosaka et al. · Journal of Bacteriology · 2003 · 126 citations · Full text

<i>afsS</i> is a target of AfsR, a transcriptional factor with ATPase activity that globally controls secondary metabolism in <i>Streptomyces coelicolor</i> A3(2)

Takashi Umeyama, Sueharu Horinouchi · Molecular Microbiology · 2002 · 106 citations

Accumulation of<i>S</i>-Adenosyl<scp>-l-</scp>Methionine Enhances Production of Actinorhodin but Inhibits Sporulation in<i>Streptomyces lividans</i>TK23

Dongjin Kim, Jung‐Hyun Huh, Young‐Yell Yang et al. · Journal of Bacteriology · 2003 · 101 citations · Full text

Biosynthesis, Biotransformation, Biochemistry +8