HEPATOPROTECTIVE ACTIVITY OF PANCHAGAVYA GHRITA AGAINST CARBONTETRACHLORIDE INDUCED HEPATOTOXICITY IN RATS

Abstract

Objective: To investigate the hepatoprotective activity of Panchagavya Ghrita (PG) against CCl 4 induced hepatotoxicity. Methods: The hepatoprotective activity of PG was tested against carbontetrachloride induced hepatotoxicity in albino rats. The degree of protection was determined by measuring levels of serum marker enzymes like serum glutamate oxaloacetate transaminase (SGOT) serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP) and acid phosphatase (ACP). The histological studies were also carried out. Silymarin was used as the standard drug for comparison. Results: Administration of Panchagavya Ghrita (150-300 mg/kg, p.o.) markedly prevented CCl 4 induced elevation of levels of serum GPT, GOT, ACP and ALP. The results are comparable to that of silymarin. A comparative histopathological study of liver exhibited almost normal architecture, as compared to control group. Conclusion: Treatment with Panchagavya Ghrita significantly reduced the CCl 4 induced hepatotoxicity. A comparative histological study of liver from different groups further confirmed the hepatoprotective activity of Panchagavya Ghrita.