Concepedia

Y402H complement factor H polymorphism associated with exudative age-related macular degeneration in the French population.

Nicolas Leveziel, F. Richard, Marie‐Agnès Dragon‐Durey, G. Coscas, G. Soubrane, Pascale Benlian, Frémeaux-Bacchi

PubMed · 2005 · 170 citations · 30 references

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Abstract

These results suggest the contribution of the Y402H polymorphism of the CFH gene to exudative AMD susceptibility also in the French population. This relationship with the CFH may lead to early detection and new strategies for prevention and treatment of AMD.

References

30

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A Randomized, Placebo-Controlled, Clinical Trial of High-Dose Supplementation With Vitamins C and E, Beta Carotene, and Zinc for Age-Related Macular Degeneration and Vision Loss

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Complement Factor H Polymorphism and Age-Related Macular Degeneration

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Complement Factor H Variant Increases the Risk of Age-Related Macular Degeneration

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A common haplotype in the complement regulatory gene factor H ( <i>HF1/CFH</i> ) predisposes individuals to age-related macular degeneration

Gregory S. Hageman, Don H. Anderson, Lincoln V. Johnson et al. · Proceedings of the National Academy of Sciences · 2005 · 1.9K citations · Full text