Decreased Expression and Activity of P-GIycoprotein in Rat Liver During Acute Inflammation

Homozygous disruption of the murine MDR2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

Jasper Smit, Alfred H. Schinkel, Ronald P.J. Oude Elferink et al. · Cell · 1993 · 1.5K citations

Medicine, Molecular Genetics, Pharmacology +16

[4] Isolation and use of liver cells

Peter Moldéus, Johan Högberg, Sten Orrenius · Methods in enzymology on CD-ROM/Methods in enzymology · 1978 · 1.2K citations

Life Sciences, Biotechnology, Cell Biology +11

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

Alfred H. Schinkel, Ulrich Mayer, Els Wagenaar et al. · Proceedings of the National Academy of Sciences · 1997 · 941 citations

Medicine, Pharmacokinetics, Pharmacology +11

Cell Growth & Differentiation

M E Foti, Mary Anne Mennite, Heide M. Pusztay et al. · 1992 · 561 citations

Life Sciences, Biology, Cell Biology +10

The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis

Michael Trauner, Marco Arrese, CJ Soroka et al. · Gastroenterology · 1997 · 499 citations

Life Sciences, Biochemistry, Pharmacology +17