A short amino‐terminal segment of microsomal cytochrome P‐450 functions both as an insertion signal and as a stop‐transfer sequence.

Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma.

Günter Blobel, B Dobberstein · The Journal of Cell Biology · 1975 · 3K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +12

A system for shotgun DNA sequencing

Joachim Messing, Roberto Crea, Peter H. Seeburg · Nucleic Acids Research · 1981 · 2.6K citations · Full text

Life Sciences, Genetics, Molecular Biology +16

Signal sequences

Gunnar von Heijne · Journal of Molecular Biology · 1985 · 2.2K citations

Isolation of intracellular membranes by means of sodium carbonate treatment: application to endoplasmic reticulum.

Yukio Fujiki, A L Hubbard, S Fowler et al. · The Journal of Cell Biology · 1982 · 1.8K citations · Full text

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Functional messenger RNAs are produced by SP6<i>in vitro</i>transcription of cloned cDNAs

Paul A. Krieg, Douglas A. Melton · Nucleic Acids Research · 1984 · 1.5K citations · Full text

Life Sciences, Genetics, Molecular Biology +17