Carbon tetrachloride-induced hepatotoxicity in rats - protective role of aqueous leaf extracts of Coccinia grandis.

Abstract

ABSTRACT: The present study was conducted to evaluate the hepatoprotective effects of an aqueous leaf extract of Coccinia grandis on carbon tetrachloride (CCl4) induced liver damage in albino rats. Wistar albino rats weighing around 180-200g were used. Toxicity was induced by using 30 % CCl4 suspended in olive oil (1.0 ml/kg body wt intraperitoneal) after every 72 hrs for 3doses. The aqueous leaf extract at a dose of 250mg/kg was administered orally by intragastric tube for 10 days. Blood and liver tissue were collected for the assessment of serum marker enzymes such as ALT, AST and ALP. The liver tissue was used for histopathological assessment.