The functional versatility of CREM is determined by its modular structure.

Rapid and efficient site-specific mutagenesis without phenotypic selection.

Thomas A. Kunkel · Proceedings of the National Academy of Sciences · 1985 · 7.3K citations · Full text

Engineering, Reverse Genetics, Efficient Site-specific Mutagenesis +14

The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins

William Landschulz, Peter F. Johnson, Steven L. McKnight · Science · 1988 · 3.5K citations

Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133

Gustavo González, Marc Montminy · Cell · 1989 · 2.5K citations

Somatostatin Gene Transcription, Molecular Regulation, Cellular Physiology +17

A rapid micrqpreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells

Nancy C. Andrews, Douglas V. Faller · Nucleic Acids Research · 1991 · 2.3K citations · Full text

Dna Sequencing, Mammalian Cells, Natural Sciences +10

CREB: a Ca ²⁺ -Regulated Transcription Factor Phosphorylated by Calmodulin-Dependent Kinases

Morgan Sheng, Margaret A. Thompson, Michael E. Greenberg · Science · 1991 · 1.5K citations