Pulmonary resistance and compliance with concurrent radioactive sulfur distribution in dogs breathing S³⁵O₂

Abstract

Ten dogs breathed S 35 O 2 via a tracheal cannula in concentrations ranging from 1.8 to 148 p p.m. There was a decrease in the compliance of the lungs and thorax after 10–15 minutes of inhalation, and an immediate and marked increase in the nonelastic resistance to breathing. S 35 was found to be highest in concentration in the trachea, lungs, and hilar lymph nodes, and next highest in the kidneys and esophagus. A relatively uniform and low concentration was noted in other tissues, such as the heart muscle, liver, spleen and striated muscle. S 35 O 2 when inhaled was absorbed quickly, distributed widely to many tissues and readily gained access to many tissues, including the brain. Submitted on April 28, 1959