MedicineCardiologyPharmacologyCardiovascular PharmacotherapyContraceptionReproductive EndocrinologyCardiovascular DiseaseCardiovascular Drug SafetyCerebrovascular DiseaseIschemic Heart DiseaseLipid DisordersThrombosisAdverse Cardiovascular Drug EventsLipid Profile Changes
Three cases of ischaemic cardio-vascular accidents are reported under progestative treatment; the drug used was chlormadinone acétate (0,5 mg daily) in one patients, and noréthistérone (5 mg daily) in two others. The accident was observed in two cases at the end of the second menstrual cycle and in one case after three years. Lipid abnormalities have been detected in the three cases: minor type IV (two patients) and mixed hyperlipidaemia (one patient).