Dipeptidyl peptidase-4 inhibition by gemigliptin prevents abnormal vascular remodeling via NF-E2-related factor 2 activation

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

Masaaki Komatsu, Satoshi Waguri, Keiko Taguchi et al. · Nature Cell Biology · 2010 · 2.4K citations

Life Sciences, Cell Biology, Molecular Biology +14

p62/SQSTM1 Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

Ashish Jain, Trond Lamark, Eva Sjøttem et al. · Journal of Biological Chemistry · 2010 · 1.5K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62

Alexandria Lau, Xiao-Jun Wang, Fei Zhao et al. · Molecular and Cellular Biology · 2010 · 842 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

The Influence of GLP-1 on Glucose-Stimulated Insulin Secretion

Lise Kjems, Jens J. Holst, Aage Vølund et al. · Diabetes · 2003 · 580 citations · Full text

Medicine, Endocrinology, Pharmacology +17

Dipeptidyl Peptidase 4 Is a Novel Adipokine Potentially Linking Obesity to the Metabolic Syndrome

Daniela Lamers, Susanne Famulla, Nina Wronkowitz et al. · Diabetes · 2011 · 578 citations · Full text

Life Sciences, Biochemistry, Endocrinology +17