CD45 specifically modulates binding of Lck to a phosphopeptide encompassing the negative regulatory tyrosine of Lck.

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

Christine Koch, Deborah H. Anderson, Michael F. Moran et al. · Science · 1991 · 1.9K citations

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

André Veillette, Michael A. Bookman, Eva Horak et al. · Cell · 1988 · 1.4K citations

Signal Transduction, Autoimmune Disease, T-regulatory Cell +9

Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck

André Veillette, Michael A. Bookman, Eva Horak et al. · Nature · 1989 · 665 citations

Signal Transduction, Signaling Pathway, Molecular Pathway +9

Activation and suppression of pp60c-src transforming ability by mutation of its primary sites of tyrosine phosphorylation

Thomas E. Kmiecik, David Shalloway · Cell · 1987 · 645 citations

Tyrosine Phosphorylation, Signal Transduction, Cell Regulation +12

Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor.

Lawrence E. Samelson, A. F. Phillips, E T Luong et al. · Proceedings of the National Academy of Sciences · 1990 · 635 citations · Full text

T-regulatory Cell, Immunology, Immunologic Mechanism +16