Berberine inhibits rat vascular smooth muscle cell proliferation and migration in vitro and improves neointima formation after balloon injury in vivo

Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor

Avner Yayon, Michael Klagsbrun, Jeffrey D. Esko et al. · Cell · 1991 · 2.4K citations

Life Sciences, Biochemistry, Cell Biology +15

Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins

Weijia Kong, Jing Wei, Parveen Abidi et al. · Nature Medicine · 2004 · 1.4K citations

Pharmacy, Pharmacology, Pharmacotherapy +4

Crystal Structure of a Ternary FGF-FGFR-Heparin Complex Reveals a Dual Role for Heparin in FGFR Binding and Dimerization

Joseph Schlessinger, A.N. Plotnikov, Omar A. Ibrahimi et al. · Molecular Cell · 2000 · 1.2K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: Metalloproteinase inhibitors as a new therapy

Masanori Asakura, Masafumi Kitakaze, Seiji Takashima et al. · Nature Medicine · 2002 · 718 citations

Life Sciences, Biochemistry, Cardiology +7

The anti-inflammatory potential of berberine in vitro and in vivo

Chi-Li Kuo, Chin‐Wen Chi, Tsung‐Yun Liu · Cancer Letters · 2003 · 684 citations

Medicine, Medicinal Chemistry, Pharmacology +12