Synthesis of novel triazoles and a tetrazole of escitalopram as cholinesterase inhibitors

A new and rapid colorimetric determination of acetylcholinesterase activity

George L. Ellman, K. Diane Courtney, Valentino Andres et al. · Biochemical Pharmacology · 1961 · 26.9K citations

Life Sciences, Biochemistry, Pharmacology +14

Atomic Structure of Acetylcholinesterase from <i>Torpedo californica</i> : A Prototypic Acetylcholine-Binding Protein

Joel L. Sussman, Michal Harel, Felix Frolow et al. · Science · 1991 · 2.7K citations

Life Sciences, Biochemistry, Molecular Biology +17

The generalized Born/volume integral implicit solvent model: Estimation of the free energy of hydration using London dispersion instead of atomic surface area

Paul Labute · Journal of Computational Chemistry · 2008 · 496 citations

Natural Sciences, Chemistry, Computational Chemistry +16

Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase

Florian Nachon, E. Carletti, Cyril Ronco et al. · Biochemical Journal · 2013 · 465 citations

Life Sciences, Medicinal Chemistry, Pharmacology +17

Acetylcholinesterase hydrolyzes substance P

I.W. Chubb, A.J. Hodgson, G H White · Neuroscience · 1980 · 308 citations

Life Sciences, Neuroscience, Pharmacology +10