The International Journal of Developmental Biology · 2002 · 94 citations · 77 references
Life SciencesDevelopmental BiologyGeneticsEmbryogenesisMorphogenesisOrganogenesisBranching MorphogenesisEpithelial MorphogenesisHereditary Kidney DiseasesHereditary Renal DiseasesKidney DevelopmentUrogenital DevelopmentCongenital Kidney DiseaseFetal Kidney DevelopmentHuman Disease ModelsHuman Kidney DevelopmentKidney PatterningRenal Epithelial DifferentiationRenal MorphogenesisUreteric Bud Development
PAX genes play an important role in fetal development. Moreover, heterozygous mutations in several PAX genes cause human disease. Here we review the role of PAX2 in kidney development, focusing on the morphological effects of PAX2 mutations. We discuss the role of PAX2 in the context of an inhibitory field model of kidney branching morphogenesis and summarize recent progress in this area.
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WT-1 is required for early kidney development
Jordan A. Kreidberg, Hannu Sariola, Janet M. Loring et al. · Cell · 1993 · 2K citations