Activation of the insulin-signaling pathway in sciatic nerve and hippocampus of type 1 diabetic rats

The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus

New England Journal of Medicine · 1993 · 24.5K citations · Full text

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

Darren A.E. Cross, Dario R. Alessi, Philip Cohen et al. · Nature · 1995 · 5.2K citations

Signal Transduction, Molecular Physiology, Biochemistry +10

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

Konrad Talbot, Hoau-Yan Wang, Hala Kazi et al. · Journal of Clinical Investigation · 2012 · 1.8K citations · Full text

Insulin receptors are widely distributed in the central nervous system of the rat

Jana Havránková, Jesse Roth, Michael Brownstein · Nature · 1978 · 1.1K citations

Insulin Receptors, Medicine, Physiology +11

Inactivation of glycogen synthase kinase-3<i>β</i> by phosphorylation: new kinase connections in insulin and growth-factor signalling

Calum Sutherland, Ian Leighton, Philip Cohen · Biochemical Journal · 1993 · 895 citations · Full text

Insulin Signaling, Skeletal Muscle, Receptor Tyrosine Kinase +17